High-fructose diet during puberty alters the sperm parameters, testosterone concentration, and histopathology of testes and epididymis in adult Wistar rats

The consumption of fructose has increased in children and adolescents and is partially responsible for the high incidence of metabolic diseases. The lifestyle during postnatal development can result in altered metabolic programming, thereby impairing the reproductive system and fertility during adul...

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Published in:Journal of developmental origins of health and disease 2022-02, Vol.13 (1), p.20-27
Main Authors: Medaglia, Daniele Sapede Alvarenga, Vieira, Henrique Rodrigues, Silveira, Sandra da Silva, Siervo, Gláucia Eloisa Munhoz de L., Marcon, Monique Suellen da Silva, Mathias, Paulo Cezar de Freitas, Fernandes, Glaura S. A.
Format: Article
Language:English
Subjects:
Adults
Animals
Disease Models, Animal
Epididymis - drug effects
Epididymis - pathology
Epididymis - physiopathology
Fertility
Food Quality
Fruits
High Fructose Corn Syrup - adverse effects
High Fructose Corn Syrup - metabolism
Homogenization
Male
Morphology
Motility
Original Article
Puberty
Puberty - blood
Puberty - metabolism
Rats
Rats, Wistar - growth & development
Rats, Wistar - metabolism
Reproductive system
Rodents
Sperm
Sperm Count - methods
Sperm Count - statistics & numerical data
Spermatogenesis
Statistical analysis
Testes
Testis - drug effects
Testis - pathology
Testis - physiopathology
Testosterone
Testosterone - analysis
Testosterone - blood
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Summary:The consumption of fructose has increased in children and adolescents and is partially responsible for the high incidence of metabolic diseases. The lifestyle during postnatal development can result in altered metabolic programming, thereby impairing the reproductive system and fertility during adulthood. Therefore, the aim of this study was to evaluate the effect of a high-fructose diet in the male reproductive system of pubertal and adult rats. Male Wistar rats (30 d old) were assigned to four different groups: Fr30, which received fructose (20%) in water for 30 d and were euthanized at postnatal day (PND) 60; Re-Fr30, which received fructose (20%) for 30 d and were euthanized at PND 120; and two control groups C30 and Re-C30, which received water ad libitum and were euthanized at PND 60 and 120, respectively. Fructose induced an increase in abnormal seminiferous tubules with epithelial vacuoles, degeneration, and immature cells in the lumen. Moreover, Fr30 rats showed altered spermatogenesis and daily sperm production (DSP), as well as increased serum testosterone concentrations. After discontinuing high-fructose consumption, DSP and sperm number decreased significantly. We observed tissue remodeling in the epididymis, with a reduction in stromal and epithelial compartments that might have influenced sperm motility. Therefore, we concluded that fructose intake in peripubertal rats led to changes in the reproductive system observed both during puberty and adulthood.
ISSN:2040-1744
2040-1752
DOI:10.1017/S2040174420001385