Oropharyngeal Dysphagia in Older People is Associated with Reduced Pharyngeal Sensitivity and Low Substance P and CGRP Concentration in Saliva

Substance P (SP) and Calcitonine gene-related peptide (CGRP) are released by sensory nerve fibers in the oropharynx. Patients with oropharyngeal dysphagia (OD) present reduced oropharyngeal sensitivity and low SP concentration in saliva. We aimed to assess the concentration of salivary SP and CGRP i...

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Bibliographic Details
Published in:Dysphagia 2022-02, Vol.37 (1), p.48-57
Main Authors: Tomsen, Noemí, Ortega, Omar, Nascimento, Weslania, Carrión, Silvia, Clavé, Pere
Format: Article
Language:English
Subjects:
Aged
Biomarkers
Body fluids
Calcitonin Gene-Related Peptide
Deglutition Disorders
Dysphagia
Electrical stimuli
Gastroenterology
Gerontology
Hepatology
Humans
Imaging
Intracellular
Medicine
Medicine & Public Health
Older people
Original Article
Oropharynx
Otorhinolaryngology
Pharynx
Radiology
Saliva
Saliva - chemistry
Sarcopenia
Sensory neurons
Substance P
Substance P - analysis
Water content
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Summary:Substance P (SP) and Calcitonine gene-related peptide (CGRP) are released by sensory nerve fibers in the oropharynx. Patients with oropharyngeal dysphagia (OD) present reduced oropharyngeal sensitivity and low SP concentration in saliva. We aimed to assess the concentration of salivary SP and CGRP in healthy volunteers, and older people without and with OD, and the relationship with pharyngeal sensory threshold. We included 15 healthy volunteers, 14 healthy elderly and 14 elderly with OD. Swallow function was assessed by videofluoroscopy (VFS). Pharyngeal sensory threshold was assessed by intrapharyngeal electrical stimulation. Hydration and phase angle were assessed by bioimpedance. Saliva samples were collected with a Salivette® to determine SP and CGRP concentration by ELISA. Elderly patients with OD presented impaired safety of swallow (PAS 4.38 ± 0.77 p  
ISSN:0179-051X
1432-0460
DOI:10.1007/s00455-021-10248-w