3‐Pyrazolyl‐oxindoles as efficient nucleophiles for construction of 3,3′‐diheterocycle substituted oxindoles using chitosan as reusable catalyst in water

A facile, one‐pot, environmentally benign and chitosan‐catalyzed protocol for the construction of a novel 3,3′‐diheterocycle substituted oxindole framework by three‐component reaction between 3‐pyrazolyl‐oxindoles, salicylaldehydes, and malononitrile in water is reported. This protocol provides seve...

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Bibliographic Details
Published in:Journal of heterocyclic chemistry 2022-02, Vol.59 (2), p.388-393
Main Authors: Liu, Li, Wang, Qing‐He, Li, Yue, Wu, Ming‐Shu
Format: Article
Language:English
Subjects:
Catalysts
Chitosan
Column chromatography
Malononitrile
Nucleophiles
Substitutes
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Summary:A facile, one‐pot, environmentally benign and chitosan‐catalyzed protocol for the construction of a novel 3,3′‐diheterocycle substituted oxindole framework by three‐component reaction between 3‐pyrazolyl‐oxindoles, salicylaldehydes, and malononitrile in water is reported. This protocol provides several advantages including readily available starting materials, a simple operation, without the need of purification by column chromatography, reusable catalyst.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.4390