Tuning the surface charge properties of chitosan nanoparticles

[Display omitted] •Chitosan nanoparticles at different pH (2 to 9) were prepared.•pH dependent morphology and zeta potential of chitosan nanoparticles studied.•pH dependent extent of protonation for chitosan nanoparticles evaluated.•COMSOL simulation correlate pH dependent surface charge of chitosan...

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Bibliographic Details
Published in:Materials letters 2022-02, Vol.308, p.131114, Article 131114
Main Authors: Athavale, Rujuta, Sapre, Nidhi, Rale, Vinay, Tongaonkar, Satish, Manna, Gouranga, Kulkarni, Atul, Shirolkar, Mandar M.
Format: Article
Language:English
Subjects:
Biomaterials
Biomedical materials
Charge density
Chitosan
Materials science
Nanoparticles
Parameters
Simulation and modelling
Stability analysis
Surface charge
Surfaces
Zeta potential
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Summary:[Display omitted] •Chitosan nanoparticles at different pH (2 to 9) were prepared.•pH dependent morphology and zeta potential of chitosan nanoparticles studied.•pH dependent extent of protonation for chitosan nanoparticles evaluated.•COMSOL simulation correlate pH dependent surface charge of chitosan nanoparticles.•Surface zeta potential of nanoparticles were evaluated for >365 days for all pH. Surface charge density (SCD) or zeta potential is a practically important parameter in the case of chitosan nanoparticles (CSNPs) for the biomedical applications. In this paper, we have demonstrated the pH dependent zeta potential stability behavior of CSNPs. The pH dependent SCD of CSNPs has been simulated using experimental parameters. The time dependent stability of CSNPs was evaluated for more than 3.15 × 107 s (or more than 365 days), which shows that at acidic pH CSNPs are highly stable while it is lost at neutral and basic pH.
ISSN:0167-577X
1873-4979
DOI:10.1016/j.matlet.2021.131114