Monoamines as Adaptive Regulators of Development: The Phenomenon and Its Mechanisms of Action

A significant number of integrative functions in the body are mediated by the monoaminergic systems: a set of low molecular weight transmitters which are biogenic amines (serotonin and dopamine), the enzymes of their metabolism, and their receptors. This makes monoamines a major component of the ner...

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Bibliographic Details
Published in:Neuroscience and behavioral physiology 2021-11, Vol.51 (9), p.1278-1285
Main Authors: Voronezhskaya, E. E., Melnikova, V. I., Ivashkin, E. G.
Format: Article
Language:English
Subjects:
Adults
Amines
Behavioral Sciences
Biogenic amines
Biomedical and Life Sciences
Biomedicine
Developmental stages
Dopamine
Eggs
Embryos
Endocrine system
Environmental conditions
Ligands
Molecular weight
Monoamines
Neural networks
Neurobiology
Neurosciences
Physiology
Regulation
Serotonin
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Summary:A significant number of integrative functions in the body are mediated by the monoaminergic systems: a set of low molecular weight transmitters which are biogenic amines (serotonin and dopamine), the enzymes of their metabolism, and their receptors. This makes monoamines a major component of the nervous and endocrine systems in the body, determining the adaptogenic capabilities of the body in continually changing environmental conditions. Using our own experimental material as an example, along with published data, we discuss the regulatory role of monoamines in development, starting with the oocyte and early cleavage stage and extending to formation of the neural networks underlying behavior. The classical ligand-receptor mechanism is considered, along with the mechanism of noncanonical modification of intracellular proteins (monoaminylation) and their contribution to adaptive regulation at different stages of development. The role of monoamines as a conservative factor binding environmental signals and the physiology of the developing body is discussed.
ISSN:0097-0549
1573-899X
DOI:10.1007/s11055-021-01191-2