Radiochromic Fricke gels with eriochrome cyanine R for radiotherapy dosimetry

The chelator eriochrome cyanine R (ECR) in aqueous solutions forms metal complexes with Fe(III) ions with 1:1 (metal:ligand) stoichiometry. Because ECR absorbs light in the visible spectrum at different wavelengths for its free and complexed forms, this ligand may behave as a dose marker in a Fricke...

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Bibliographic Details
Published in:Radiation physics and chemistry (Oxford, England : 1993) England : 1993), 2022-02, Vol.191, p.109830, Article 109830
Main Authors: Almeida, Wandson dos Santos de, Alves, Anderson Vinícius Silva, Oliveira, Willyan Farias, Silveira, Matheus Augusto Libório da, Souza, Susana Oliveira de, d’Errico, Francesco, Sussuchi, Eliana Midori
Format: Article
Language:English
Subjects:
3D dosimetry
Absorption spectra
Aqueous solutions
Coordination compounds
Dosimeters
Dosimetry
Eriochrome cyanine R
Gels
Ionizing radiation
Iron
Iron(IIII) complex
Ligands
Polyvinyl alcohol
Radiation dosage
Radiation therapy
Radiotherapy
Sensitivity
Stoichiometry
Sulfuric acid
Visible spectrum
Wavelengths
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Summary:The chelator eriochrome cyanine R (ECR) in aqueous solutions forms metal complexes with Fe(III) ions with 1:1 (metal:ligand) stoichiometry. Because ECR absorbs light in the visible spectrum at different wavelengths for its free and complexed forms, this ligand may behave as a dose marker in a Fricke gel (FG) dosimeter. This is the first investigation of the influence of the organic ligand ECR in Fricke gels produced with a polyvinyl alcohol matrix cross-linked with glutaraldehyde (FGECR). The concentrations of sulfuric acid, ECR, and Fe(II) ions were varied in the FG synthesis in order to optimize the detector sensitivity to ionizing radiation. For comparison sake, FG synthesized with xylenol orange (FGXO) was also produced. The formation of the Fe(III)-ECR complex after irradiation has two absorption bands in the visible region. The absorbance intensities vary linearly with the absorbed dose in the range of 0.0–40.0 Gy. The FGECR and FGXO showed similar properties: sensitivity of (0.072 ± 0.001) Gy-1 and (0.079 ± 0.001) Gy-1; and diffusion of (0.192 ± 0.006) mm2 h-1 and (0.184 ± 0.022) mm2 h-1, respectively. FGECR has some advantages for application in radiotherapy, as it presented sensitivity for low doses, whose minimum detectable dose was 0.67 Gy, with maximum optical absorption at low energy wavelengths, ideal for measuring radiation dose by optical tomography, and it has a high saturation dose. Therefore, FGECR has the potential for dosimetric studies in radiotherapy, including flash radiotherapy, which deposits high doses in extremely short times. •The eriochrome cyanine R has the potential for 3D dosimetry.•Fricke gel-PVA is promising for studies in flash radiation therapy.•The radiochromic dosimeter has unique characteristics as a dosimetric material.•Fe3+ ion complex with eriochrome cyanine R ligand is formed post-irradiation.
ISSN:0969-806X
1879-0895
DOI:10.1016/j.radphyschem.2021.109830