UV/Vis absorption spectroelectrochemistry of folic acid

UV/Vis absorption spectroelectrochemistry is a very promising analytical technique due to the complementary information that is simultaneously obtained from electrochemistry and spectroscopy. In this work, this technique is used in a parallel configuration to study the oxidation of folic acid in alk...

Full description

Saved in:
Bibliographic Details
Published in:Journal of solid state electrochemistry 2022, Vol.26 (1), p.29-37
Main Authors: Olmo, F., Rodriguez, A., Colina, A., Heras, A.
Format: Article
Language:English
Subjects:
Absorption
Acids
Analytical Chemistry
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Condensed Matter Physics
Electrochemical oxidation
Electrochemistry
Energy Storage
Folic acid
Optical communication
Original Paper
Oxidation
Pharmaceuticals
Physical Chemistry
Tablets
Vitamin B
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:UV/Vis absorption spectroelectrochemistry is a very promising analytical technique due to the complementary information that is simultaneously obtained from electrochemistry and spectroscopy. In this work, this technique is used in a parallel configuration to study the oxidation of folic acid in alkaline medium. Herein, UV/Vis absorption spectroelectrochemistry has been used to detect both the oxidation products and the folic acid consumed at the electrode/solution interface, allowing us to develop an analytical protocol to quantify vitamin B9 in pharmaceutical tablets. Linear ranges of three orders of magnitude have been achieved in basic medium (pH = 12.9), obtaining high repeatability and low detection limits. The spectroelectrochemical determination of folic acid in pharmaceutical tablets at alkaline pH values is particularly interesting because of the changes that occur in the optical signal during the electrochemical oxidation of FA, providing results with very good figures of merit and demonstrating the utility and versatility of this hyphenated technique, UV/Vis absorption spectroelectrochemistry.
ISSN:1432-8488
1433-0768
DOI:10.1007/s10008-021-05026-5