Association of sleep duration with type 2 diabetes and impaired glucose tolerance

Aims/hypothesis The aim of this study was to assess the relationship between sleep duration and type 2 diabetes or impaired glucose tolerance (IGT). Methods Anthropometric measurements and self-reported sleep duration were determined in a cross-sectional sample of 323 men and 417 women aged 21-64 ye...

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Bibliographic Details
Published in:Diabetologia 2007-11, Vol.50 (11), p.2298-2304
Main Authors: Chaput, J.-P, Després, J.-P, Bouchard, C, Tremblay, A
Format: Article
Language:English
Subjects:
Adult
Appetite
Area Under Curve
Biological and medical sciences
blood glucose
Blood Glucose - metabolism
Body Composition
Body fat
Body Mass Index
Body weight
Diabetes
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - genetics
Diabetes Mellitus, Type 2 - physiopathology
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
energy intake
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Food intake
Fundamental and applied biological sciences. Psychology
Glucose
Glucose homeostasis
Glucose Intolerance - genetics
Glucose Intolerance - physiopathology
Glucose tolerance
Glucose Tolerance Test
Homeostasis
Humans
Hunger
Insulin
Insulin - blood
Insulin resistance
Medical sciences
Middle Aged
Obesity
Overweight
Sleep
Sleep - physiology
Sleep deprivation
Sleep loss
Sleep. Vigilance
Time Factors
Vertebrates: nervous system and sense organs
weight gain
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Summary:Aims/hypothesis The aim of this study was to assess the relationship between sleep duration and type 2 diabetes or impaired glucose tolerance (IGT). Methods Anthropometric measurements and self-reported sleep duration were determined in a cross-sectional sample of 323 men and 417 women aged 21-64 years from the Quebec Family Study. Glucose homeostasis indicators were compared between short (5-6 h), 'normal' (7-8 h) and long (9-10 h) sleeper groups. Results Using adults with 7-8 h of sleep as a reference, the adjusted odds ratio for type 2 diabetes/IGT was 1.58 (1.13-2.31) for those with 9-10 h of sleep and 2.09 (1.34-2.98) for those with 5-6 h of sleep, after adjustment for potential confounding variables. The short and long sleepers presented significantly higher total insulin AUC (p < 0.05), whereas total glucose AUC was not different between the three sleeper groups in both sexes. The mean glucose area below fasting glucose concentrations was significantly higher in short (p < 0.01) and long sleepers (p < 0.05) compared with 'normal' sleepers, and significantly higher in short (p < 0.05) compared with long sleepers in both sexes. Conclusions/interpretation The present study provides evidence that short- and long-duration sleep times are associated with type 2 diabetes/IGT in adults, even after adjustment for several confounders. These results also showed that the lower glucose concentrations at the end of the OGTT were observed in short sleepers. According to the glucostatic theory of appetite control, this represents a stimulus that can trigger episodes of hunger and spontaneous food intake, which may explain at least in part the greater risk of overweight displayed by short sleepers, as shown in previous studies.
ISSN:0012-186X
1432-0428
DOI:10.1007/s00125-007-0786-x