Core-satellite assembly of gold nanoshells on solid gold nanoparticles for a color coding plasmonic nanosensor

We present core-satellite assemblies comprising a solid gold nanoparticle as the core and hollow decahedral gold nanoshells as satellites for tuning the optical properties of the plasmonic structure for sensing. The core-satellite assemblies were fabricated on a substrate via the layer-by-layer asse...

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Bibliographic Details
Published in:Analyst (London) 2021-12, Vol.147 (1), p.155-164
Main Authors: Le, Nguyen H, Cathcart, Nicole, Kitaev, Vladimir, Chen, Jennifer I. L
Format: Article
Language:English
Subjects:
Adenosine triphosphate
Assemblies
Biomolecules
Color coding
Coupling (molecular)
Finite difference time domain method
Gold
Metal Nanoparticles
Microscopy
Microscopy, Electron, Scanning
Morphology
Nanoparticles
Nanosensors
Nanoshells
Nucleic acids
Optical properties
Plasmonics
Satellites
Substrates
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Summary:We present core-satellite assemblies comprising a solid gold nanoparticle as the core and hollow decahedral gold nanoshells as satellites for tuning the optical properties of the plasmonic structure for sensing. The core-satellite assemblies were fabricated on a substrate via the layer-by-layer assembly of nanoparticles linked by DNA. We used finite-difference time-domain simulations to help guide the geometrical design, and characterized the optical properties and morphology of the solid-shell nanoparticle assemblies using darkfield microscopy, single-nanostructure spectroscopy, and scanning electron microscopy. Plasmon coupling yielded resonant peaks at longer wavelengths in the red to near-infrared range for solid-shell assemblies compared with solid-solid nanoparticle assemblies. We examined sensing with the solid-shell assemblies using adenosine triphosphate (ATP) as a model target and ATP-aptamer as the linker. Binding of ATP induced disassembly and led to a decrease in the scattering intensity and a color change from red to green. The new morphology of the core-satellite assembly enabled plasmonic color-coding of multiplexed sensors. We demonstrate this potential by fabricating two types of assemblies using DNA linkers that target different molecules - ATP and a model nucleic acid. Our work expands the capability of chip-based plasmonic nanoparticle assemblies for the analysis of multiple, different types of biomolecules in small sample sizes including the microenvironment and single cells. Two different compositions of plasmonic nanoparticle assemblies simultaneously detect nucleic acid and ATP.
ISSN:0003-2654
1364-5528
DOI:10.1039/d1an01421h