0D/1D Heterojunction Implant with Electro‐Mechanobiological Coupling Cues Promotes Osteogenesis

Mimicking the natural bone extracellular matrix containing intrinsic topography and electrical signals is an effective way to modulate bone regeneration. However, simultaneously coupling of the intrinsic mechanobiology and electrical cues of implant to modulate bone regeneration remains ignored. Her...

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Bibliographic Details
Published in:Advanced functional materials 2021-12, Vol.31 (50), p.n/a
Main Authors: Huang, Xiao, Xing, Jun, Wang, Zhengao, Han, Jin, Wang, Renxian, Li, Changhao, Xiao, Cairong, Lu, Fang, Zhai, Jinxia, Zhou, Zhengnan, Li, Yangfan, Zhou, Lei, Song, Zhiguo, Chen, Dafu, Yu, Peng, Ning, Chengyun, Jiang, Xieyuan
Format: Article
Language:English
Subjects:
Biomechanics
Biomedical materials
bismuth oxide nanodots
Bismuth oxides
Bismuth trioxide
Bone marrow
Bone-implant interfaces
Coupling
Differentiation (biology)
Electric fields
electro‐mechanobiology
heterojunction
Heterojunctions
Kinases
Materials science
Modulus of elasticity
osteogenesis
Regeneration (physiology)
Stem cells
Surgical implants
Titanium dioxide
titanium dioxide nanocones
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Summary:Mimicking the natural bone extracellular matrix containing intrinsic topography and electrical signals is an effective way to modulate bone regeneration. However, simultaneously coupling of the intrinsic mechanobiology and electrical cues of implant to modulate bone regeneration remains ignored. Here, the authors report in situ designation of titanium dioxide (TiO2) nanocone/bismuth oxide (Bi2O3) nanodot heterojunctions on bone implant surface to electro‐biomechanically trigger osseointegration at bone/implant interface. TiO2 nanocone/Bi2O3 nanodot heterojunctions exhibit built‐in electric field at the nanoscale interface and elastic modulus equivalent to that of bone tissue. The nano‐heterojunctions significantly promoted the attachment, spreading, and osteogenic differentiation of bone marrow mesenchymal stem cells in vitro, and the osteogenesis in vivo. The authors also show that the effects of nano‐heterojunctions on osteogenesis are mediated by yes‐associated protein biomechanical signal pathway and intracellular enrichment induced Phosphatidylinositol 3‐kinase signal pathway. Their findings highlight the coupling of topographical and electric parameters of biomaterials for modulating cell behaviors. The 0D/1D heterojunction implant is constructed by growing discretely distributed bismuth oxide nanodots in situ upon titanium dioxide nanocones on a titanium implant surface. The 0D/1D heterojunction has the bone tissue mimetic nanotopology and the built‐in electric field at the nanoscale interface, achieving electro‐biomechanical coupling to regulate bone regeneration.
ISSN:1616-301X
1616-3028
DOI:10.1002/adfm.202106249