Rasmussen syndrome in a tropical environment: a study of six (6) observations

BackgroundIn sub-Saharan Africa, encephalitis of various etiologies is a major public health problem and Rasmussen syndrome is rarely diagnosed due to under-medicalization. The objective of this study is to describe the clinical and neuroradiological forms, especially since this affection is little...

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Published in:The Egyptian Journal of Neurology, Psychiatry and Neurosurgery Psychiatry and Neurosurgery, 2021-11, Vol.57 (1), p.1-8
Main Authors: Guelngar Carlos Othon, Touré, Mohamed Lamine, Barry, Mamadou Ciré, Diakité, Mamady, Mahadi Konaté, Bachir Abdoul Djibo Hamani, Sakadi, Foksouna, Hassane, Fatimata Djibo, Camara, Naby, Dago François Kassa, Bah, Fatimatou Korka, Camara, Doussou, Millimono, Victorine, Condé, Salematou, Sakho, Aminata, Diallo, Mohamed Tafsir, Barry, Souleymane Djigué, Diallo, Mamadou Saliou, Fodé Mohamed Soumah, Yaya, Aminou Sanni, Daouya, Douna Granga, Said Abdallah Rafkat, Konaté, Mamady, Souleymane Mbara Diallo, Fodé Abass Cissé, Cissé, Amara
Format: Article
Language:English
Subjects:
Chronic encephalitis
Convulsions & seizures
Epilepsy
Hemiatrophy
Rasmussen syndrome
SSA
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Summary:BackgroundIn sub-Saharan Africa, encephalitis of various etiologies is a major public health problem and Rasmussen syndrome is rarely diagnosed due to under-medicalization. The objective of this study is to describe the clinical and neuroradiological forms, especially since this affection is little known in sub-Saharan Africa as evidenced by the scarcity of publications.ResultsA retrospective, descriptive and analytical study of six (6) cases of Rasmussen syndrome, shows that it is an unrecognized disease in Africa. Men were more represented with a frequency of 67% with a young age. The clinical picture dominated by 100% seizures, mental deterioration and hemiparesis. The etiology is still questionable, probably autoimmune in our study.ConclusionRasmussen syndrome accounts for 3% in 219 patients hospitalized for epileptic conditions. This study shows a clinical profile dominated by recurrent epileptic seizures refractory to the drugs Phenobarbital, Valproic Acid and Carbamazepine, the only antiepileptics available in the country. These results are valid for therapeutic and prognostic discussion.
ISSN:1110-1083
1687-8329
DOI:10.1186/s41983-021-00409-x