Photoredox-catalyzed 2,2,2-trifluoroethylation and 2,2-difluoroethylation of alkenes with concomitant introduction of a quinoxalin-2(1H)-one moiety

A photoredox-catalyzed strategy for difunctionalization of alkenes with readily available quinoxalin-2(1H)-ones and inexpensive ICH2CF3/ICH2CF2H was developed. This reaction proceeded under mild conditions, affording the corresponding three-component coupling products in moderate to high yields and...

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Bibliographic Details
Published in:Organic chemistry frontiers an international journal of organic chemistry 2021-11, Vol.8 (23), p.6597-6602
Main Authors: Yang, Xiu, Wei-Dong, Meng, Xiu-Hua Xu, Huang, Yangen
Format: Article
Language:English
Subjects:
Alkenes
Organic chemistry
Photoredox catalysis
Regioselectivity
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Summary:A photoredox-catalyzed strategy for difunctionalization of alkenes with readily available quinoxalin-2(1H)-ones and inexpensive ICH2CF3/ICH2CF2H was developed. This reaction proceeded under mild conditions, affording the corresponding three-component coupling products in moderate to high yields and excellent regioselectivity. It provides a new protocol to access valuable CF3CH2- and HCF2CH2-containing compounds.
ISSN:2052-4110
2052-4110
DOI:10.1039/d1qo01170g