Influence of the MCT1-T1470A polymorphism (rs1049434) on repeated sprint ability and blood lactate accumulation in elite football players: a pilot study

Purpose The aim of this study is to investigate the influence of the MCT1 T1470A polymorphism (rs1049434) on repeated sprint ability (RSA) and lactate accumulation after RSA testing. Methods Twenty-six elite Italian male football players (age: 17.7 ± 0.78 years; height: 179.2 ± 7.40 cm; weight: 72.1...

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Bibliographic Details
Published in:European journal of applied physiology 2021-12, Vol.121 (12), p.3399-3408
Main Authors: Massidda, M., Flore, L., Kikuchi, N., Scorcu, M., Piras, F., Cugia, P., Cięszczyk, P., Tocco, F., Calò, C. M.
Format: Article
Language:English
Subjects:
Adolescent
Alleles
Athletic Performance - physiology
Biomedical and Life Sciences
Biomedicine
Football
Gene polymorphism
Genotype
Genotyping
Heterozygotes
Homozygotes
Human Physiology
Humans
Lactates - blood
Lactic acid
Male
Monocarboxylic Acid Transporters - genetics
Occupational Medicine/Industrial Medicine
Original Article
Physical Endurance - genetics
Polymorphism
Polymorphism, Single Nucleotide
Running - physiology
Soccer
Sports Medicine
Symporters - genetics
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Summary:Purpose The aim of this study is to investigate the influence of the MCT1 T1470A polymorphism (rs1049434) on repeated sprint ability (RSA) and lactate accumulation after RSA testing. Methods Twenty-six elite Italian male football players (age: 17.7 ± 0.78 years; height: 179.2 ± 7.40 cm; weight: 72.1 ± 5.38 kg) performed RSA testing (6 × 30-m sprints with an active recovery between sprints), and lactate measurements were obtained at 1, 3, 5, 7, and 10 min post-exercise. Genotyping for the MCT1 T1470A polymorphism was performed using PCR. Results Genotype distributions were in Hardy–Weinberg equilibrium, being 42% wildtype (A/A), 46% heterozygotes (T/A), and 12% mutated homozygotes (T/T). Significant differences between genotypic groups were found in the two final sprint times of the RSA test. Under a dominant model, carriers of the major A-allele (Glu-490) in the dominant model showed a significantly lower sprint time compared to footballers with the T/T (Asp/Asp) genotype (5th Sprint time: A/A + T/A = 4.60 s vs TT = 4.97 s, 95% CI 0.07–0.67, p  = 0.022; 6th Sprint: A/A + T/A = 4.56 s vs T/T = 4.87 s, 95% CI 0.05–0.57, p  = 0.033). Conclusions The T1470A (Glu490Asp) polymorphism of MCT1 was associated with RSA. Our findings suggest that the presence of the major A-allele (Glu-490) is favourable for RSA in football players.
ISSN:1439-6319
1439-6327
DOI:10.1007/s00421-021-04797-z