Polydopamine functionalized mesoporous silica as ROS-sensitive drug delivery vehicles for periodontitis treatment by modulating macrophage polarization

Periodontitis is recognized as the major cause of tooth loss in adults, posing an adverse impact on systemic health. In periodontitis, excessive production of reactive oxygen species (ROS) at the inflamed site culminates in periodontal destruction. In this study, a novel ROS-responsive drug delivery...

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Published in:Nano research 2021-12, Vol.14 (12), p.4577-4583
Main Authors: Bai, Bingbing, Gu, Chaoyu, Lu, Xiaohui, Ge, Xingyu, Yang, Junling, Wang, Chenfei, Gu, Yongchun, Deng, Aidong, Guo, Yuehua, Feng, Xingmei, Gu, Zhifeng
Format: Article
Language:English
Subjects:
Alveolar bone
Animal models
Anti-inflammatory agents
Atomic/Molecular Structure and Spectra
Biomedicine
Biotechnology
Bone loss
Chemistry and Materials Science
Condensed Matter Physics
Cytokines
Drug delivery
Drug delivery systems
Gum disease
Inflammation
Macrophages
Materials Science
Microenvironments
Minocycline
Nanoparticles
Nanotechnology
Periodontitis
Phenotypes
Polarization
Reactive oxygen species
Research Article
Silica
Silicon dioxide
Teeth
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Summary:Periodontitis is recognized as the major cause of tooth loss in adults, posing an adverse impact on systemic health. In periodontitis, excessive production of reactive oxygen species (ROS) at the inflamed site culminates in periodontal destruction. In this study, a novel ROS-responsive drug delivery system based on polydopamine (PDA) functionalized mesoporous silica nanoparticles was developed for delivering minocycline hydrochloride (MH) to treat periodontitis. The outer PDA layer and the inner MH of the nanoparticles acted as ROS scavengers and anti-inflammatory agents, respectively. Under the synergistic action of PDA and MH, macrophages were polarized from the pro-inflammatory M1 to the anti-inflammatory M2 phenotype. The in vitro experiments provided convincing evidence that PDA could scavenge ROS effectively, and the expression of pro-inflammatory cytokines was attenuated and the secretion of anti-inflammatory cytokines was enhanced through M1 to M2 polarization of macrophages with the cooperation of MH. In addition, the results obtained from the periodontitis rat models demonstrated that the synergetic effect of PDA and MH prevented alveolar bone loss without causing any adverse effect. Taken together, the results from the present investigation provide a new strategy to remodel the inflammatory microenvironment by inducing the polarization of macrophages from M1 toward M2 state for the treatment of periodontitis.
ISSN:1998-0124
1998-0000
DOI:10.1007/s12274-021-3376-1