K2Mn32 NPs with High T1‐Relaxivity Attributable to Water Coordination on the Mn(II) Center for Gastrointestinal Tract MR Imaging

The lack of acid stability in the stomach and of temporal stability when moving through the gastrointestinal (GI) tract has made the development of oral magnetic resonance imaging (MRI) contrast agents based on the platform of Gd3+–complexes problematic.On the other hand, the negative contrast enhan...

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Bibliographic Details
Published in:Advanced healthcare materials 2021-10, Vol.10 (20)
Main Authors: Kandanapitiye, Murthi S, Dassanayake, Thiloka M, Dassanayake, Arosha C, Shelestak, John, Clements, Robert J, Can, Fernando, Huang, Songping D
Format: Article
Language:English
Subjects:
Biocompatibility
Contrast agents
Contrast media
Gadolinium
Gastric juice
Gastrointestinal system
Gastrointestinal tract
Magnetic resonance imaging
Manganese
Metal oxides
Nanoparticles
Pigments
Stability
Toxicity
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Summary:The lack of acid stability in the stomach and of temporal stability when moving through the gastrointestinal (GI) tract has made the development of oral magnetic resonance imaging (MRI) contrast agents based on the platform of Gd3+–complexes problematic.On the other hand, the negative contrast enhancement produced by the T2‐weighted magnetic metal oxide nanoparticles (NPs) often renders the image readout difficult. Biocompatible NPs of the manganese Prussian blue analog K2Mn3[FeII(CN)6]2 exhibit extremely high stability under the acidic conditions of the gastric juice. Additionally, the high r1 relaxivity, low toxicity, and high temporal stability of such NPs offer great potential for the development of a true T1‐weighted oral contrast agent for MRI of the entire GI tract.
ISSN:2192-2640
2192-2659
DOI:10.1002/adhm.202100987