Applying eco‐friendly micellar liquid chromatography for the simultaneous determination of two ternary mixtures utilized for cold treatment using monolithic column

Rapid, isocratic, and sensitive micellar liquid chromatographic methods were developed successfully for the analysis of two ternary mixtures: phenylephrine hydrochloride (PHE), ibuprofen (IBU) and chlorpheniramine maleate (CP) (mixture I), and pseudoephedrine hydrochloride (PSE), IBU and CP (mixture...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the Chinese Chemical Society (Taipei) 2021-09, Vol.68 (9), p.1686-1696
Main Authors: Abu El‐Enin, Mohamed A., Salem, Yomna A., El‐Ashry, Saadia M., Hammouda, Mohammed E. A.
Format: Article
Language:English
Subjects:
chlorpheniramine maleate
Chromatography
Cold treatment
Flow velocity
Ibuprofen
Ions
Liquid chromatography
micellar liquid chromatographic method
monolithic column
phenylephrine hydrochloride
Phosphoric acid
pseudoephedrine hydrochloride
Separation
Sodium dodecyl sulfate
Solvents
tablets
Triethylamine
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Rapid, isocratic, and sensitive micellar liquid chromatographic methods were developed successfully for the analysis of two ternary mixtures: phenylephrine hydrochloride (PHE), ibuprofen (IBU) and chlorpheniramine maleate (CP) (mixture I), and pseudoephedrine hydrochloride (PSE), IBU and CP (mixture II) in their synthetic mixtures and pharmaceutical dosage forms. Analytical separation was achieved in 7 min using monolithic column adopting UV detector at 233 and 218 nm for mixture I and II, respectively. For both mixtures, a micellar mobile phase solution composed of 0.15 M sodium dodecyl sulphate, 15% n‐propanol, and 0.3% triethylamine adjusted to pH 4.0 by 0.02 M phosphoric acid was utilized applying a flow rate of 1.2 ml/min. The methods were fully validated in accordance with the International Conference on Harmonization guidelines. The proposed methods were linear in the range of 0.5–20.0 μg/ml for PHE and 10.0–400.0 μg/ml for IBU, and CP 0.25–8.0 μg/ml (mixture I) and in the range of 3.0–60.0 μg/ml for PSE and 20.0–400.0 μg/ml for IBU, and CP 0.2–4.0 μg/ml (mixture II) and methanol was utilized as diluting solvent. Furthermore, the proposed methods exhibited good accuracy and repeatability (R.S.D. 
ISSN:0009-4536
2192-6549
DOI:10.1002/jccs.202100093