A Review: Mechanism of Phyllanthus urinaria in Cancers—NF-κB, P13K/AKT, and MAPKs Signaling Activation

Phyllanthus urinaria has been characterized for its several biological and medicinal effects such as antiviral, antibacterial, anti-inflammatory, anticancer, and immunoregulation. In recent years, Phyllanthus urinaria has demonstrated potential to modulate the activation of critical pathways such as...

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Published in:Evidence-based complementary and alternative medicine 2021-08, Vol.2021, p.4514342-9
Main Authors: Saahene, Roland Osei, Agbo, Elvis, Barnes, Precious, Yahaya, Ewura Seidu, Amoani, Benjamin, Nuvor, Samuel Victor, Okyere, Perditer
Format: Article
Language:English
Subjects:
AKT protein
Angiogenesis
Antitumor agents
Antiviral drugs
Apoptosis
Breast cancer
Cancer
Cancer therapies
Cell death
Cell growth
Cell proliferation
Drug development
Immunoregulation
Inflammation
Kinases
Metastases
Natural products
NF-κB protein
Phyllanthus urinaria
Review
Reviews
Signal transduction
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Summary:Phyllanthus urinaria has been characterized for its several biological and medicinal effects such as antiviral, antibacterial, anti-inflammatory, anticancer, and immunoregulation. In recent years, Phyllanthus urinaria has demonstrated potential to modulate the activation of critical pathways such as NF-κB, P13K/AKT, and ERK/JNK/P38/MAPKs associated with cell growth, proliferation, metastasis, and apoptotic cell death. To date, there is much evidence indicating that modulation of cellular signaling pathways is a promising approach to consider in drug development and discovery. Thus, therapies that can regulate cancer-related pathways are longed-for in anticancer drug discovery. This review’s focus is to provide comprehensive knowledge on the anticancer mechanisms of Phyllanthus urinaria through the regulation of NF-κB, P13K/AKT, and ERK/JNK/P38/MAPKs signaling pathways. Thus, the review summarizes both in vitro and in vivo effects of Phyllanthus urinaria extracts or bioactive constituents with emphasis on tumor cell apoptosis. The literature information was obtained from publications on Google Scholar, PubMed, Web of Science, and EBSCOhost. The key words used in the search were “Phyllanthus” or “Phyllanthus urinaria” and cancer. P. urinaria inhibits cancer cell proliferation via inhibition of NF-κB, P13K/AKT, and MAPKs (ERK, JNK, P38) pathways to induce apoptosis and prevents angiogenesis. It is expected that understanding these fundamental mechanisms may help stimulate additional research to exploit Phyllanthus urinaria and other natural products for the development of novel anticancer therapies in the future.
ISSN:1741-427X
1741-4288
DOI:10.1155/2021/4514342