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Prognostic significance of human papillomavirus status and treatment modality in hypopharyngeal cancer
Background Management of hypopharynx cancer is often extrapolated from larynx cancer. This report analyses treatment patterns and survival limited to hypopharynx cancer using the National Cancer Database (NCDB). Methods There are 9314 patients diagnosed with hypopharynx cancer between 2004 and 2016....
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Published in: | Head & neck 2021-10, Vol.43 (10), p.3042-3052 |
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Main Authors: | , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Background
Management of hypopharynx cancer is often extrapolated from larynx cancer. This report analyses treatment patterns and survival limited to hypopharynx cancer using the National Cancer Database (NCDB).
Methods
There are 9314 patients diagnosed with hypopharynx cancer between 2004 and 2016. The association between treatment modality and survival was analyzed using Kaplan–Meier survival curves and multivariable Cox regression.
Results
Five‐year overall survival ranged from 45% for stage I to 21% for stage IVB. Treatment modality did not influence survival in stage I/II. For stage III/IV, chemoradiation and surgery + adjuvant therapy were equivalent. Surgery yielded improved survival for T4 disease. Human papillomavirus (HPV)‐positive tumors were present in 21% and were associated with improved hazard ratio of death (0.60, p = |
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ISSN: | 1043-3074 1097-0347 |
DOI: | 10.1002/hed.26793 |