Effect of Proteinase from Aspergillus fumigatus on Blood Plasma Proteins

Extracellular proteinase of the opportunistic Aspergillus fumigatus D-1 strain (molecular weight ~33 kDa, pI 4.6) was isolated. It was shown that proteinase hydrolyzes casein, fibrin, fibrinogen, albumin, and hemoglobin to varying degrees. However, proteolytic activity with respect to globular prote...

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Bibliographic Details
Published in:Moscow University biological sciences bulletin 2021-04, Vol.76 (2), p.71-76
Main Authors: Osmolovskiy, A. A., Schmidt, L., Orekhova, A. V., Kreyer, V. G., Baranova, N. A., Egorov, N. S.
Format: Article
Language:English
Subjects:
Aspergillus fumigatus
Biochemistry
Biomedical and Life Sciences
Blood
Casein
Cell Biology
Fibrin
Fibrinogen
Fibrinolysis
Hemoglobin
Life Sciences
Molecular weight
Municipalities
Plant Sciences
Plasma proteins
Proteinase
Proteolysis
Short Communications
Yard waste
Zoology
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Summary:Extracellular proteinase of the opportunistic Aspergillus fumigatus D-1 strain (molecular weight ~33 kDa, pI 4.6) was isolated. It was shown that proteinase hydrolyzes casein, fibrin, fibrinogen, albumin, and hemoglobin to varying degrees. However, proteolytic activity with respect to globular proteins of blood plasma was comparable to fibrinolytic activity. Proteinase did not coagulate human fibrinogen and bovine fibrinogen; it also did not coagulate human and rabbit blood plasma without dilution and when diluted twice. The plasminogen-activating activity of A. fumigatus D-1 extracellular proteinase was found, which may indicate its ability to indirect fibrinolysis.
ISSN:0096-3925
1934-791X
DOI:10.3103/S0096392521020048