TiO2 Nanotube Arrays Modified With Zinc and Loaded with Hydrophilic and Hydrophobic Drugs

TiO2 Nanotube Arrays Modified With Zinc and Loaded with Hydrophilic and Hydrophobic Drugs

TiO2 nanotube arrays were prepared by anodization of Ti plat, then modified by hydrothermal method in Zn(NO3)2 solution and finally loaded alendronate or ibuprofen drugs by vacuum drying. The experimental results show that the amount of two drugs loaded on the modified TiO2 nanotube array is increas...

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Bibliographic Details
Published in:IOP conference series. Materials Science and Engineering 2017-09, Vol.230 (1)
Main Authors: Zhang, Fengfen, Zhan, Xiaowei, Yang, Xiaojuan, Xiao, Xiufeng
Format: Article
Language:eng
Subjects:
Arrays
Drugs
Ibuprofen
Nanotubes
Sustained release
Titanium dioxide
Zinc
Online Access:Get full text
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Summary:TiO2 nanotube arrays were prepared by anodization of Ti plat, then modified by hydrothermal method in Zn(NO3)2 solution and finally loaded alendronate or ibuprofen drugs by vacuum drying. The experimental results show that the amount of two drugs loaded on the modified TiO2 nanotube array is increased. The release behavior of the modified nanotubes including burst release and sustained relase. high hours before release. The modified TiO2 nanotube arrays were more slowly released during the sustained release than unmodified nanotubes, indicating that the Zn2+ modified nanotubes have certain sustained-release effect.
ISSN:1757-8981
1757-899X