Albumin covering maintains endothelial function upon magnetic iron oxide nanoparticles intravenous injection in rats

Magnetic iron oxide nanoparticles (IONP) present the promising instrument for broad‐spectrum of clinical applications, for example, targeted drug delivery. Reactivity of nanoparticles depends on their surface area and material. In the blood plasma IONP are getting covered with an albumin crown, so i...

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Bibliographic Details
Published in:Journal of biomedical materials research. Part A 2021-10, Vol.109 (10), p.2017-2026
Main Authors: Toropova, Yana G., Zelinskaya, Irina A., Gorshkova, Mariya N., Motorina, Daria S., Korolev, Dmitriy V., Velikonivtsev, Fedor S., Gareev, Kamil G.
Format: Article
Language:English
Subjects:
Acetylcholine - pharmacology
Albumin
Albumins
Albumins - chemistry
Animals
Aorta
Area Under Curve
Arterial Pressure - drug effects
Arteries
Biocompatibility
Biomarkers - metabolism
Blood flow
Blood plasma
Blood pressure
Drug delivery
Endothelial Cells - drug effects
Endothelial Cells - metabolism
Endothelin-1 - metabolism
Endothelins
endothelium
Femoral artery
Femoral Artery - drug effects
Femoral Artery - physiology
Heart rate
Heart Rate - drug effects
Hemodynamics
Hemodynamics - drug effects
Injection
Injections, Intravenous
Intravenous administration
Iron oxides
laser Doppler flowmetry
magnetic iron oxide nanoparticles
Magnetic Iron Oxide Nanoparticles - administration & dosage
Male
Mesenteric Arteries - drug effects
Mesenteric Arteries - physiology
Microcirculation - drug effects
Nanoparticles
Nitric oxide
Nitric Oxide - metabolism
Phenylephrine - pharmacology
protein crown
Rats
Rats, Wistar
Regional Blood Flow - drug effects
regulated perfusion
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Summary:Magnetic iron oxide nanoparticles (IONP) present the promising instrument for broad‐spectrum of clinical applications, for example, targeted drug delivery. Reactivity of nanoparticles depends on their surface area and material. In the blood plasma IONP are getting covered with an albumin crown, so it was decided to test this shell for biocompatibility. Male Wistar rats were anesthetized and underwent laparotomy. Abdominal aorta was connected to external hemodynamic loop with regulated blood flow. Hind body quarter got step‐like blood flow changing from 30 to 150 mmHg and back. This was followed with i.v. injection of IONP, albumin solution or albumin‐covered IONP and consequent similar flow changes. Central hemodynamics—heart rate and mean arterial pressure were registered throughout the experiment and no significant changes in these parameters were observed. Hind paw microcirculation level had the same dynamic in all groups under changing blood flow conditions. At the end, venous blood was collected for endothelin‐1 and NO evaluation that showed similar changes and no endothelial damage. Mesenteric arteries and femoral artery reactivity were evaluated with wire myography. Mesenteric arteries had the most relaxing function preservation after albumin‐covered IONP injection. Given data reveal advantage of albumin‐coated IONP so this can be used for further investigations as a vascular‐safe vehicle.
ISSN:1549-3296
1552-4965
DOI:10.1002/jbm.a.37193