Effect of increasing cow's milk consumption on riboflavin intake and plasma riboflavin measures in women of child-bearing age

The effect of milk consumption on riboflavin status has not been previously investigated, primarily because riboflavin biomarkers are rarely measured in human studies and the gold standard EGRac (erythrocyte glutathione reductase activation co-efficient) assay demands laborious pre-analysis sample p...

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Bibliographic Details
Published in:	Proceedings of the Nutrition Society 2021, Vol.80 (OCE3), Article E138
Main Authors:	Yeates, A. J., Pourshahidi, L. K., O'Kane, S. M., Ward, M., Mulhern, M. S., Lamers, Y., McNulty, H., Strain, J.J.
Format:	Article
Language:	eng
Subjects:	Adenine Biomarkers Consumption Cow's milk Diet Dilution Erythrocytes Flavin mononucleotide Flavin-adenine dinucleotide Glutathione Glutathione reductase Liquid chromatography Mass spectrometry Mass spectroscopy Milk Plasma Reductases Riboflavin Sample preparation Vitamin B
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Summary:	The effect of milk consumption on riboflavin status has not been previously investigated, primarily because riboflavin biomarkers are rarely measured in human studies and the gold standard EGRac (erythrocyte glutathione reductase activation co-efficient) assay demands laborious pre-analysis sample preparation. At weeks 0 and 12, participants completed a 24hr dietary recall and provided a blood sample with plasma analysed for riboflavin and its coenzyme forms, flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) by isotope-dilution liquid chromatography-tandem mass spectrometry. Increasing cow's milk consumption resulted in a significant increase in riboflavin intake and an increase in the proportion of women meeting the RNI compared to the control.
ISSN:	0029-6651 1475-2719