Long-term exposure to low doses of aluminum affects mineral content and microarchitecture of rats alveolar bone

Aluminum (Al) is one of the most found elements in nature in many forms, and human exposure can be quite common. Therefore, it is important to investigate the effects of exposure to Al mainly at low doses and for a prolonged period, in order to simulate human exposure in the periodontium, an importa...

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Bibliographic Details
Published in:Environmental science and pollution research international 2021-09, Vol.28 (33), p.45879-45890
Main Authors: Souza-Monteiro, Deiweson, Ferreira, Railson de Oliveira, Eiró, Luciana Guimarães, de Oliveira Lima, Leidiane Alencar, Balbinot, Gabriela Souza, da Paz, Simone Patricia Aranha, Albuquerque, Alan Rodrigo Leal, Collares, Fabricio Mezzomo, Angélica, Rômulo Simões, Pessanha, Sofia, do Socorro Ferraz Maia, Cristiane, Lima, Rafael Rodrigues
Format: Article
Language:English
Subjects:
Aluminum
Aluminum chloride
Alveolar bone
Aquatic Pollution
Atmospheric Protection/Air Quality Control/Air Pollution
Blood circulation
Bone composition
Computer architecture
Distilled water
Earth and Environmental Science
Ecotoxicology
Environment
Environmental Chemistry
Environmental Health
Environmental science
Exposure
Fourier analysis
Fourier transforms
Infrared analysis
Infrared spectroscopy
Mineral composition
Periodontium
Raman spectroscopy
Research Article
Rodents
Spectroscopic analysis
Spectrum analysis
Teeth
Waste Water Technology
Water Management
Water Pollution Control
X ray microtomography
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Summary:Aluminum (Al) is one of the most found elements in nature in many forms, and human exposure can be quite common. Therefore, it is important to investigate the effects of exposure to Al mainly at low doses and for a prolonged period, in order to simulate human exposure in the periodontium, an important structure for support and protection of the teeth. This investigation aimed to study the aluminum chloride (AlCl 3 ) toxicological effects in the mineral composition and micromorphology of the alveolar bone of rats. Two groups of eight male Wistar rats were used for the experiment. AlCl 3 group was exposed to AlCl 3 orally at a dose of 8.3 mg/kg/day for 60 days, while the control group received only distilled water. After that, the mandibles were collected and submitted to the following analyses: Fourier transform infrared spectroscopy, Raman spectroscopy, and X-ray microtomography analysis; blood was also collected for determination of Al circulating levels. Our data showed that AlCl 3 was capable of increasing Al circulating levels in blood. It was able to promote changes in the mineral content and triggers significant changes in the mineralized bone microstructure, such as number and thickness of trabeculae, being associated with alveolar bone-loss.
ISSN:0944-1344
1614-7499
DOI:10.1007/s11356-021-13937-z