Pharmaceutical biotechnological potential of filamentous fungi isolated from textile industry

The need for more effective drugs for the treatment of infectious diseases as well as for general applications including wound healing and burn surgery, has guided efforts for the discovery of new compounds of medical interest. Microorganisms found in textile industrial waste have the ability to pro...

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Bibliographic Details
Published in:Archives of microbiology 2021-09, Vol.203 (7), p.3933-3944
Main Authors: Bernal, Suzan Prado Fernandes, Gritti, Micaela Andrea, dos Santos, Viviane Piccin, Ottoni, Júlia Ronzella, de Oliveira, Valéria Maia, Peichoto, Maria Elisa, Passarini, Michel Rodrigo Zambrano
Format: Article
Language:English
Subjects:
Antiinfectives and antibacterials
Antimicrobial activity
Antimicrobial agents
Biochemistry
Biomedical and Life Sciences
Biotechnology
Cell Biology
Collagen
Collagenase
Ecology
Enzymes
Fungi
Industrial wastes
Infectious diseases
Life Sciences
Metabolites
Microbial Ecology
Microbiology
Microorganisms
Minimum inhibitory concentration
Original Paper
Pharmaceuticals
Secondary metabolites
Textile industry
Textile industry wastewaters
Wastewater
Wound healing
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Summary:The need for more effective drugs for the treatment of infectious diseases as well as for general applications including wound healing and burn surgery, has guided efforts for the discovery of new compounds of medical interest. Microorganisms found in textile industrial waste have the ability to produce a variety of enzymes and/or secondary metabolites including molecules of pharmaceutical interest. The present work investigated the biotechnological potential of filamentous fungi isolated from textile industry wastewater for the production of collagenase and antimicrobial metabolites. From 28 isolates assayed, Sarocladium sp. ITF33 showed specific collagenolytic activity with values of 7.62 and 9.04 U mg −1 for the intracellular and extracellular fractions, respectively. The isolate Penicillium sp. ITF28 showed the best antimicrobial activity, reaching MIC ranging from 1.0 to 0.0625 mg mL −1 against five pathogenic bacteria. Molecular analyzes suggest that the isolate Sarocladium sp. ITF 33 can be considered a species not yet described. The results of the present work encourage studies of characterization and purification of the enzymes and secondary metabolites produced by the isolates found aiming future applications in the medical and pharmaceutical fields.
ISSN:0302-8933
1432-072X
DOI:10.1007/s00203-021-02379-3