Anticancer Property of Lanthanide Sulfate Nanostructure Against Neuroblastoma-Neuro2a Cell Line

A novel lanthanum (III) complex with 8-Hq = 8-hydroxy quinoline and phen-dione = 1,10-phenanthroline-5,6-dione was synthesized using the reflux method. The complex was characterized using elemental analyses, cyclic voltammetry technique, electronic absorption spectroscopy, H-NMR spectroscopy, X-ray...

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Bibliographic Details
Published in:BioNanoScience 2021-09, Vol.11 (3), p.696-702
Main Authors: Haghighat, Mojtaba, Naroie, Afsoon, Rezvani, Alireza, Hakimi, Mohammad, Saravani, Hamideh, Darroudi, Majid, Amini, Abbas, Sabaghan, Mohamad, Khatami, Mehrdad
Format: Article
Language:English
Subjects:
Absorption spectroscopy
Anticancer properties
Biological and Medical Physics
Biomaterials
Biophysics
Cell culture
Cell viability
Circuits and Systems
Cytotoxicity
Engineering
Gravimetry
Lanthanum
Magnetic resonance spectroscopy
Morphology
Nanostructure
Nanotechnology
Neuroblastoma
NMR
NMR spectroscopy
Nuclear magnetic resonance
Quinoline
Scanning electron microscopy
Spectrum analysis
Thermal stability
Toxicity
X ray powder diffraction
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Summary:A novel lanthanum (III) complex with 8-Hq = 8-hydroxy quinoline and phen-dione = 1,10-phenanthroline-5,6-dione was synthesized using the reflux method. The complex was characterized using elemental analyses, cyclic voltammetry technique, electronic absorption spectroscopy, H-NMR spectroscopy, X-ray powder diffraction, and scanning electron microscopy. Then, La 2 O 2 (SO 4 ) nanostructure (NS La-s) was obtained from the lanthanum (III) complex as a precursor after calcination at 700 °C for 4 h. The thermal stability of nanostructure was determined by the thermal gravimetric method. SEM results showed that the morphology of La 2 O 2 (SO 4 ) was spiral-like. The cytotoxicity of La-s NS was studied using cell viability assay on neuroblastoma-N2a cell line culture. The results ranked the cytotoxicity activity of La-s NS in N2a cell line to IC 50  =  ~ 22 μg mL − 1 .
ISSN:2191-1630
2191-1649
DOI:10.1007/s12668-021-00887-6