Anticarcinogenic Effect of Chitosan Nanoparticles Containing Syzygium aromaticum Essential Oil or Eugenol Toward Breast and Skin Cancer Cell Lines

The development of new green drugs is crucial because of the side effects and resistance to chemotropic drugs. Essential oils with a broad range of bioactivities such as antioxidant and anticancer activities are great resources for research and investigation. In this study, ingredients of the used S...

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Bibliographic Details
Published in:	BioNanoScience 2021-09, Vol.11 (3), p.678-686
Main Authors:	Valizadeh, Alireza, Khaleghi, Ali Asghar, Alipanah, Hiva, Zarenezhad, Elham, Osanloo, Mahmoud
Format:	Article
Language:	eng
Subjects:	Anticancer properties Antioxidants Antitumor agents Biological and Medical Physics Biomaterials Biophysics Breast cancer Chitosan Circuits and Systems Drug development Drug resistance Drugs Engineering Essential oils Eugenol Gas chromatography In vivo methods and tests Ingredients Mass spectrometry Mass spectroscopy Melanoma Nanoparticles Nanotechnology Oils & fats Side effects Skin cancer Sustainable development Syzygium aromaticum Tumor cell lines
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Summary:	The development of new green drugs is crucial because of the side effects and resistance to chemotropic drugs. Essential oils with a broad range of bioactivities such as antioxidant and anticancer activities are great resources for research and investigation. In this study, ingredients of the used Syzygium aromaticum essential oil (SAEO) were identified using gas chromatography-mass spectrometry (GC-MS) analysis. The antioxidant effect of eugenol (major ingredients) was more potent than SAEO; their half-maximal inhibitory concentrations (IC 50 s) were observed at 109 and 204 μg mL −1 . Chitosan nanoparticles containing SAEO (158 ± 4 nm) and eugenol (200 ± 13 nm) were prepared using the ionic gelation method. The potency of the nanoformulations was significantly more than their non-formulated states on both examined cell lines. IC 50 s of chitosan nanoparticles containing SAEO and eugenol against melanoma (A-375) cells were obtained at 73 and 79 μg mL −1 ; these values on breast (MDA-MB-468) cells were 177 and 51 μg mL −1 . Results showed that chitosan nanoparticles containing eugenol could be considered chemo-preventative or anticancer agents in further in vivo studies.
ISSN:	2191-1630 2191-1649