Green synthesis of 1,7-bis(substituted phenyl)1,6-heptadiene-3,5-diones and their inhibition of human pathogenic bacteria

Green synthesis of 1,7-bis(substituted phenyl)1,6-heptadiene-3,5-diones and their inhibition of human pathogenic bacteria

Curcumin analogs are synthesized with solid support under the concept of green chemistry, i.e. in the absence of organic solvents or hazardous chemicals using silica-sulfuric acid under solvent free conditions. Their structures are established through infrared, NMR, and mass spectroscopy and element...

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Bibliographic Details
Published in:Toxicological and environmental chemistry 2021-02, Vol.103 (2), p.129-136
Main Authors: Manga Veni, Pudi, Kilaru, Padma Suhasini
Format: Article
Language:eng
Subjects:
Analogs
Antibacterial activity
Bacteria
Ciprofloxacin
Curcumin
Gram-negative bacteria
Green chemistry
Heptadiene
Infrared analysis
Mass spectroscopy
NMR
Nuclear magnetic resonance
Organic solvents
Silica
Silicon dioxide
Solvents
Sulfuric acid
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Summary:Curcumin analogs are synthesized with solid support under the concept of green chemistry, i.e. in the absence of organic solvents or hazardous chemicals using silica-sulfuric acid under solvent free conditions. Their structures are established through infrared, NMR, and mass spectroscopy and elemental analysis. The antibacterial activities of the synthesized curcumin analogs are evaluated against three human pathogenic Gram negative bacteria, taking ciprofloxacin as standard compound. Most compounds exhibit some antibacterial activity, with an efficacy depending upon nature and position of the phenyl substituents.
ISSN:0277-2248
1029-0486