Effect of Sorafenib on Sex Hormone Levels in Male Swiss Albino Mice

Background: Hormones play a vital role in initiating and maintenance of male reproductive or testicular function which includes the production of androgens and spermatozoa. Testosterone is essential for the initiation and maintenance of spermatogenesis. FSH is responsible for the stimulation of sper...

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Published in:Research journal of pharmacy and technology 2021-07, Vol.14 (7), p.3883-3888
Main Authors: Shetty, Surekha D., Bairy K., Laxminarayana, Prasad, AM, Nayak B., Satheesha, Aithal P., Ashwini
Format: Article
Language:English
Subjects:
Albinism
Androgens
Animals
Cancer
Chemotherapy
Cytotoxicity
Drug dosages
Enzymes
Fertility
Hypothalamus
Infertility
Kidney cancer
Sperm
Spermatogenesis
Targeted cancer therapy
Testes
Testosterone
Variance analysis
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Summary:Background: Hormones play a vital role in initiating and maintenance of male reproductive or testicular function which includes the production of androgens and spermatozoa. Testosterone is essential for the initiation and maintenance of spermatogenesis. FSH is responsible for the stimulation of spermatogenesis. Semen analysis and hormone evaluation are essential parameters in the diagnosis of infertility in males. Objective: The aim of the present study is to evaluate the effect of sorafenib on FSH and intratesticular testosterone levels in male Swiss albino mice. Materials and Methods: The animals were segregated into control, positive control, and treatment groups (n=6). Treatment group received 25, 50 and 100 mg/kg body weight of sorafenib orally for seven consecutive days at intervals of 24 hours between two administrations. Positive control group received 100 mg/kg body weight of imatinib. The animals were sacrificed at the end of 1st, 2nd, 4th, 5th, 7th and 10th week after the last exposure to sorafenib. Results: The intratesticular testosterone level was significantly (P
ISSN:0974-3618
0974-360X
0974-306X
DOI:10.52711/0974-360X.2021.00674