Protective effects of astaxanthin from Haematococcus pluvialis on the survival and oxidative stress of zebrafish embryos induced by microcystin-LR

This study evaluated the individual effects of microcystin-LR (MC-LR) with different concentrations (0, 10, 20, 30, 40 and 50 μg L −1 ) and the combined influences with astaxanthin (10 and 100 μg L −1 ) from Haematococcus pluvialis on the survival and oxidative stress of zebrafish embryos. Results s...

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Bibliographic Details
Published in:Journal of applied phycology 2021-08, Vol.33 (4), p.2261-2271
Main Authors: Dong, Jing, Li, Chenlu, Dai, Dujuan, Zhang, Man, Gao, Yunni, Li, Xuejun, Li, Mei, Zhang, Jingxiao, Wang, Xianfeng, Zhou, Chuanjiang
Format: Article
Language:English
Subjects:
Algae
Animal embryos
Antioxidants
Aquaculture
Astaxanthin
Biological stress
Biomedical and Life Sciences
Contamination
Danio rerio
Deformation effects
Dietary supplements
Ecology
Embryos
Exposure
Fish
Freshwater & Marine Ecology
Freshwater fishes
Glutathione
Glutathione peroxidase
Haematococcus pluvialis
Hatching
Juveniles
Life Sciences
Malondialdehyde
Microcystin-LR
Mortality
Oxidative stress
Peroxidase
Plant Physiology
Plant Sciences
Reactive oxygen species
Superoxide dismutase
Survival
Toxicity
Zebrafish
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Summary:This study evaluated the individual effects of microcystin-LR (MC-LR) with different concentrations (0, 10, 20, 30, 40 and 50 μg L −1 ) and the combined influences with astaxanthin (10 and 100 μg L −1 ) from Haematococcus pluvialis on the survival and oxidative stress of zebrafish embryos. Results showed that the reactive oxygen species (ROS), malondialdehyde (MDA), mortality and deformity rate were increased in the presence of MC-LR accompanied with the reduction of the glutathione peroxidase (GSH), superoxide dismutase (SOD), the total antioxidant capacity (T-AOC) and hatching rate of the zebrafish embryo. The higher the MC-LR concentration was, the stronger the developmental and oxidative stress response ( p < 0.05). This study confirmed that the supplementation of astaxanthin could significantly alleviate the toxic effects of MC-LR on zebrafish embryos. The mortality and deformity rates decreased significantly in the combined exposure group compared with the only MC-LR exposure group, and the decreasing rates were positively correlated with the astaxanthin concentration. Astaxanthin could also significantly improve the oxidative stress response and damage caused by MC-LR. The ROS and MDA contents of juvenile fish decreased, whereas GSH, SOD and T-AOC increased significantly with astaxanthin supplementation. Therefore, astaxanthin might be a suitable diet supplement against the MC-LR contamination of pond aquaculture.
ISSN:0921-8971
1573-5176
DOI:10.1007/s10811-021-02448-6