Entomopathogenic fungi Beauveria sp. and Aspergillus sclerotiorum can produce secondary metabolite quinidine

Entomopathogenic fungi have been reported to produce secondary metabolite quinolines. One of the quinoline alkaloids is quinidine, a compound that has antiarrhythmic properties, therefore it has an economic important value. The aim of the experiment reported here was to study the potency of entomopa...

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Bibliographic Details
Published in:IOP conference series. Earth and environmental science 2020-02, Vol.457 (1), p.12032
Main Authors: Anggiani, J P, Listiyowati, S, Rahayu, G
Format: Article
Language:English
Subjects:
Aspergillus
Beauveria
Biomass
Chloroform
Crude extract
Dextrose
Dry weight
Entomopathogenic fungi
Evaporators
Fungi
High-performance liquid chromatography
HPLC
incubation period
Liquid chromatography
Metabolites
Organic compounds
Potatoes
Quinidine
Quinoline
Quinolines
Room temperature
secondary metabolic
static
Weight
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Summary:Entomopathogenic fungi have been reported to produce secondary metabolite quinolines. One of the quinoline alkaloids is quinidine, a compound that has antiarrhythmic properties, therefore it has an economic important value. The aim of the experiment reported here was to study the potency of entomopathogenic fungi Beauveria sp. IPBCC. 19.1499 and Aspergillus sclerotiorum IPBCC.19.1500 in producing quinidine. The quinidine was obtained from a broth culture of each fungus grown in Potato Dextrose Broth medium (pH 6.2, static, room temperature) for 7, 14, and 21 days incubation period. At harvest, broth of each culture was extracted using chloroform. The extract then dried using an evaporator. The presence of quinidine in the extracted was detected by HPLC. The dry weight of fungal biomass and the crude extract of broth culture were also recorded. HPLC analysis showed that quinidine was produced by both fungi tested. The species of the fungus and incubation period significantly affected quinidine production. Beauveria sp. IPBCC.19.1499, in general, produced quinidine in higher concentration than that of A. sclerotiorum IPBCC.19.1500. The quinidine concentration increased significantly with increasing incubation period. The quinidine concentration was also positively correlated with biomass dry weight, while the crude extract dry weight was negatively correlated with quinidine concentration.
ISSN:1755-1307
1755-1315
DOI:10.1088/1755-1315/457/1/012032