The structural and surface properties of Al-doped hydroxyapatite (Ca5(PO4)3OH) nanorods and their applications for pH-induced drug delivery

•Al-doped hydroxyapatite nanorods with a large surface area were synthesized.•The surface of Al-HAp nanorods was modified with hyaluronic acid (HA).•The Al-HAp/HA compound showed a higher DOX loading capacity. In this paper, we reported Al-doped hydroxyapatite (Al-HAp) nanorods with surface function...

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Bibliographic Details
Published in:Journal of alloys and compounds 2021-10, Vol.879, p.160414, Article 160414
Main Authors: Fan, Qingyu, Fan, Fan, Xu, Wei, Zhang, Hao, Liu, Na
Format: Article
Language:English
Subjects:
Al doping
Anticancer properties
Biocompatibility
Cancer treatment
Crystal structure
Doxorubicin
Drug delivery
Hyaluronic acid
Hydroxyapatite
Nanorods
Pore size
Specific surface
Surface area
Surface properties
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Summary:•Al-doped hydroxyapatite nanorods with a large surface area were synthesized.•The surface of Al-HAp nanorods was modified with hyaluronic acid (HA).•The Al-HAp/HA compound showed a higher DOX loading capacity. In this paper, we reported Al-doped hydroxyapatite (Al-HAp) nanorods with surface functionalization of hyaluronic acid (HA) for pH-responsive delivery of doxorubicin (DOX) for cancer treatment. The specific surface area and the crystal structure of both HAp and Al-HAp are studied. It is learned that the HAp and Al-HAp have similar crystal structures, but Al-HAp shows 10% larger specific surface area than HAp, which results in 30% higher DOX loading capacity than HAp nanorods, due to the increased surface area and enlarged pore size by Al doping. Moreover, the DOX loaded Al-HAp/HA was highly pH-responsive and exhibited outstanding biocompatibility and significantly enhanced anti-cancer killing effects.
ISSN:0925-8388
1873-4669
DOI:10.1016/j.jallcom.2021.160414