Effect of Radiotherapy Dose Rates on Early Intestinal Toxicity

OBJECTIVE The aim of the present study was to investigate early histopathological changes in small intestinal tissue caused by radiotherapy (RT) applications with varying dose rates in rats. METHODS Thirty rats were divided into 3 groups. The first and second groups were irradiated at 300 MU/min and...

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Bibliographic Details
Published in:Türk onkoloji dergisi 2016-01, Vol.31 (1)
Main Author: UNAL, Dilek
Format: Article
Language:eng ; tur
Subjects:
Abdomen
Animals
Apoptosis
Cancer therapies
Cell division
Chemotherapy
Diarrhea
Hypoxia
Investigations
Radiation therapy
Small intestine
Statistical analysis
Tumors
Variance analysis
Vomiting
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Summary:OBJECTIVE The aim of the present study was to investigate early histopathological changes in small intestinal tissue caused by radiotherapy (RT) applications with varying dose rates in rats. METHODS Thirty rats were divided into 3 groups. The first and second groups were irradiated at 300 MU/min and 600 MU/min, respectively. The third was a control group. On day 7 following RT application, small intestine tissue samples were obtained. RESULTS Mucosal thickness was significantly lower in the 300 MU/min group, compared to the other groups, and thickness was significantly lower in the 600 MU/min group, compared to the control group. Villus length was significantly decreased in the 300 MU/min group, compared to the other groups, and villus width was significantly increased in the control group, compared to the other groups. CONCLUSION RT application with high dose may be less toxic for tissue with high risk for acute toxicity, such as that of the small intestine.
ISSN:1300-7467
2717-8978
DOI:10.5505/tjo.2016.1399