Prognostic Significance of Microsatellite Instability in Turkish Patients with Stage II and III Colorectal Cancer

Objectives: Microsatellite instability (MSI) – a form of pervasive erratic expansion of microsatellites – can be identified in 15?20% of all patients with sporadic colorectal cancer (CRC). To gain further insight into the prognostic value of MSI in CRC, we sought to investigate this issue in a nonse...

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Bibliographic Details
Published in:Eurasian journal of medical investigation 2021, Vol.5 (1), p.62
Main Author: Deligonul, Adem
Format: Article
Language:eng ; tur
Subjects:
Cancer therapies
Chemotherapy
Colorectal cancer
Elective surgery
Medical prognosis
Medicine
Mortality
Oncology
Radiation therapy
Tumors
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Summary:Objectives: Microsatellite instability (MSI) – a form of pervasive erratic expansion of microsatellites – can be identified in 15?20% of all patients with sporadic colorectal cancer (CRC). To gain further insight into the prognostic value of MSI in CRC, we sought to investigate this issue in a nonselected sample of Turkish patients seen in daily practice and to establish whether the MSI status is associated with survival outcomes. We specifically focused on patients with stage 2 and stage 3 CRC because they are a heterogeneous group in need of an improved clinical management. Methods: A total of 81 patients were enrolled into the study. MSI analysis was performed a dedicated platform and classified into three types, as follows: microsatellite stability (MSS), low microsatellite instability (MSI-L), and high microsatellite instability (MSI-H). Disease-free survival (DFS) and overall survival (OS) served as the main outcome measures. Results: Patients with MSI-H had a significantly higher frequency of right colon tumors compared with those with MSI-L/MSS. Moreover, no cases of rectal tumor were observed in the former group (p=0.002). As a result, the use of radiotherapy was limited to patients with MSI-L/MSS (p=0.02). Patients with MSI-H did not differ from those with MSI-L/ MSS both in terms of DFS and OS. Conclusion: Our study demonstrates that Turkish patients with proximal colon cancer more frequently have MSI-H compared to those with distal colon cancer. However, the MSI status did not have a significant impact on survival outcomes.
ISSN:2602-3164
2602-3164
DOI:10.14744/ejmi.2021.19999