An environmentally benign synthesis of Tetrabutylphosphonium tribromide (TBPTB) - a versatile and efficient phase transfer reagent for organic transformations

Tetrabutylphosphonium tribromide (TBPTB), a mild and versatile reagent, has been synthesized following an environmentally benign protocol. The new reagent possesses inherent phase transfer properties which facilitates organic reactions in aqueous medium. Thermal stability of the reagent which enable...

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Bibliographic Details
Published in:Green chemistry letters and reviews 2021-04, Vol.14 (2), p.425-434
Main Authors: Kuotsu, Visekhonuo, Nakro, Vevosa, Yanger, Imkong, Lotha, Tsenbeni N., Tzudir, Ketiyala, Sinha, Upasana Bora, Jamir, Latonglila
Format: Article
Language:English
Subjects:
Aminobenzothiazoles
aqueous reactions
Aqueous solutions
Chemical reactions
Cyanamides
Irradiation
microwave reactions
Organic compounds
phase-transfer reagent
Reagents
Recyclability
Synthesis
Tetrabutylphosphonium tribromide
Thermal stability
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Summary:Tetrabutylphosphonium tribromide (TBPTB), a mild and versatile reagent, has been synthesized following an environmentally benign protocol. The new reagent possesses inherent phase transfer properties which facilitates organic reactions in aqueous medium. Thermal stability of the reagent which enables organic reactions under microwave irradiation and recyclability of the spent reagent are special attributes of the new reagent. These properties collectively provide an opportunity for facile, practical, and eco-friendly synthesis of a wide range of pharmaceutically significant and specialty organic compounds such as bromo-organics, isothiocyanates, cyanamides and 2-aminobenzothiazoles in excellent yields on-water under microwave irradiation.
ISSN:1751-8253
1751-7192
DOI:10.1080/17518253.2021.1929511