Solubility and Dissolution Study of Prochlorperazine Maleate Nanoparticle Prepared by Design of Experiment

The objective of the present work was to improve the solubility and dissolution rate of the poorly water-soluble drug, prochlorperazine maleate (PCM), by preparing nanoparticles using wet media milling method. The first screening design (Plackett–Burman) was applied to screen the significant factors...

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Bibliographic Details
Published in:BioNanoScience 2021-06, Vol.11 (2), p.567-578
Main Authors: Raval, Mihir, Bagada, Hina L.
Format: Article
Language:English
Subjects:
Biological and Medical Physics
Biomaterials
Biophysics
Circuits and Systems
Comminution
Dependent variables
Design of experiments
Design optimization
Dissolution
Electron microscopy
Engineering
Independent variables
Nanoparticles
Nanotechnology
Particle size
Poloxamers
Size reduction
Solubility
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Summary:The objective of the present work was to improve the solubility and dissolution rate of the poorly water-soluble drug, prochlorperazine maleate (PCM), by preparing nanoparticles using wet media milling method. The first screening design (Plackett–Burman) was applied to screen the significant factors among all the factors. Then, final nanoparticles were optimized by Box–Behnken design and evaluated for independent variables viz. the amount of Pluronic F127, amount of PCM, and milling speed on dependent variables such as particle size, saturated solubility, and dissolution efficiency at 5 min. The Pareto chart revealed a significant effect of three variables among all variables ( P  
ISSN:2191-1630
2191-1649
DOI:10.1007/s12668-021-00831-8