Polydiketopyrrolopyrroles Carrying Ethylene Glycol Substituents as Efficient Mixed Ion‐Electron Conductors for Biocompatible Organic Electrochemical Transistors

A comprehensive investigation of four polydiketopyrrolopyrroles (PDPPs) with increasing ethylene glycol (EG) content and varying nature of comonomer is presented, and guidelines for the design of efficient mixed ion‐electron conductors (MIECs) are deduced. The studies in NaCl electrolyte‐gated organ...

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Bibliographic Details
Published in:Advanced functional materials 2021-05, Vol.31 (20), p.n/a
Main Authors: Krauss, Gert, Meichsner, Florian, Hochgesang, Adrian, Mohanraj, John, Salehi, Sahar, Schmode, Philip, Thelakkat, Mukundan
Format: Article
Language:English
Subjects:
Aqueous solutions
Biocompatibility
bioelectronics
biosensors
Conductors
conjugated polymers
Electrolytes
Ethylene glycol
Hole mobility
Materials science
organic electronics
Semiconductor devices
structure–property relationship
Toxicity
Transistors
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Summary:A comprehensive investigation of four polydiketopyrrolopyrroles (PDPPs) with increasing ethylene glycol (EG) content and varying nature of comonomer is presented, and guidelines for the design of efficient mixed ion‐electron conductors (MIECs) are deduced. The studies in NaCl electrolyte‐gated organic electrochemical transistors (OECTs) reveal that a high amount of EG on the DPP moiety is essential for MIEC. The PDPP containing 52 wt% EG exhibits a high volumetric capacitance of 338 F cm−3 (at 0.8 V), a high hole mobility in aqueous medium (0.13 cm2 V−1 s−1), and a μC* product of 45 F cm−1 V−1 s−1. OECTs using this polymer retain 97% of the initial drain‐current after 1200 cycles (90 min of continuous operation). In a cell growth medium, the OECT‐performance is fully maintained as in the NaCl electrolyte. In vitro cytotoxicity and cell viability assays reveal the excellent cell compatibility of these novel systems, showing no toxicity after 24 h of culture. Due to the excellent OECT performance with a considerable cycling stability for 1200 cycles and an outstanding cell compatibility, these PDPPs render themselves viable for in vitro and in vivo bioelectronics. Design rules for highly efficient mixed ion electron conductors based on donor–acceptor copolymers of diketopyrrolopyrroles for bioelectronics are presented. Outstanding cell compatibility from in vitro cytotoxicity and cell viability tests as well as long‐term cycling stability demonstrate great potential for use in biosensors.
ISSN:1616-301X
1616-3028
DOI:10.1002/adfm.202010048