Sesquiterpenoids from the Whole Plants of Chloranthus holostegius and Their Anti‐inflammatory Activities

Main observation and conclusion Five new sesquiterpenoids (1—5), chloranholides A—E, along with three known compounds (6—8), were isolated from the whole plants of Chloranthus holostegius. Their structures were elucidated using the spectroscopic methods (IR, UV, HR‐ESI‐MS, 1D and 2D NMR), and their...

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Bibliographic Details
Published in:Chinese journal of chemistry 2021-05, Vol.39 (5), p.1168-1174
Main Authors: Zhan, Zhao‐Chun, Wu, Zhong‐Nan, Tang, Qing, Li, Can‐Jie, Wang, Wen‐Zhi, Zhang, Ji‐Hui, Zhuo, Xue‐Fang, Zhang, Yu‐Bo, Wang, Guo‐Cai, Li, Yao‐Lan
Format: Article
Language:English
Subjects:
Chloranthus holostegius
Crystallography
Dexamethasone
Inflammation
Lipopolysaccharides
Macrophages
NMR
NMR spectroscopy
Nuclear magnetic resonance
Sesquiterpenoids
Tumor necrosis factor
X‐ray diffraction
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Summary:Main observation and conclusion Five new sesquiterpenoids (1—5), chloranholides A—E, along with three known compounds (6—8), were isolated from the whole plants of Chloranthus holostegius. Their structures were elucidated using the spectroscopic methods (IR, UV, HR‐ESI‐MS, 1D and 2D NMR), and their absolute configurations were determined by the X‐ray crystallography and ECD calculation. Compounds 1—8 were evaluated for their anti‐inflammatory effects on LPS‐induced RAW 264.7 macrophage cells. Especially, compound 4 exhibited the most significant anti‐inflammatory activity with the secretion levels of TNF‐α and IL‐6 at 15.52% and 5.98%, respectively, better than that of dexamethasone.
ISSN:1001-604X
1614-7065
DOI:10.1002/cjoc.202000625