Iota-carrageenan prevents the replication of SARS-CoV-2 on an in vitro respiratory epithelium model

There are, except for remdesivir, no approved antivirals for the treatment or prevention of SARS- CoV-2 infections. Iota-carrageenan formulated into a nasal spray has already been proven safe and effective in viral respiratory infections. We explored this antiviral activity in Calu-3, a human respir...

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Bibliographic Details
Published in:bioRxiv 2021-04
Main Authors: Varese, Augusto, Ceballos, Ana, Palacios, Carlos Adolfo, Figueroa, Juan Manuel, Dugour, Andrea Vanesa
Format: Article
Language:English
Subjects:
Antiviral activity
Antiviral agents
Epithelium
Respiratory tract
Severe acute respiratory syndrome coronavirus 2
Sodium chloride
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Summary:There are, except for remdesivir, no approved antivirals for the treatment or prevention of SARS- CoV-2 infections. Iota-carrageenan formulated into a nasal spray has already been proven safe and effective in viral respiratory infections. We explored this antiviral activity in Calu-3, a human respiratory model cell line. A formula of iota-carrageenan and sodium chloride, as a nasal spray, already approved for human use, effectively inhibited SARS-CoV-2 infection in vitro, providing a more substantial reference for further clinical studies or developments. Competing Interest Statement The authors have declared no competing interest.
DOI:10.1101/2021.04.27.441512