Separation of Long-Lived Radionuclides on QMA Light Anion-Exchange Cartridge in Manufacture of Radiopharmaceutical Preparations Based on 18F

Sorption and elution on a QMA light anion-exchange cartridge of long-lived radionuclides formed in [ 18 O]H 2 O under irradiation of a niobium target with Havar alloy input window on a Cyclone 18/9 HC cyclotron have been studied. It was shown that more than 90% of 51 Cr and 7 Be radionuclides from i...

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Published in:Radiochemistry (New York, N.Y.) N.Y.), 2021, Vol.63 (2), p.235-242
Main Authors: Krot, V. O., Brinkevich, S. D., Brinkevich, D. I., Ivanyukovich, A. A.
Format: Article
Language:English
Subjects:
Acetonitrile
Anion exchanging
Aqueous solutions
Beryllium
Beryllium 7
Cartridges
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Chromium
Cobalt
Cyclotrons
Elution
Fluorides
Irradiation
Manganese
Niobium
Nuclear Chemistry
Potassium carbonate
Radiochemistry
Radioisotopes
Regeneration
Sorbents
Water purification
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Summary:Sorption and elution on a QMA light anion-exchange cartridge of long-lived radionuclides formed in [ 18 O]H 2 O under irradiation of a niobium target with Havar alloy input window on a Cyclone 18/9 HC cyclotron have been studied. It was shown that more than 90% of 51 Cr and 7 Be radionuclides from irradiated [ 18 O]H 2 O is sorbed on the QMA light anion-exchange cartridge. 55,56, 57,58 Co, 52,54 Mn, and 57 Ni radionuclides pass through the cartridge and are delivered into a flask with [ 18 O]H 2 O for subsequent regeneration. It was found that about 30% of cobalt and manganese radioisotopes and also ~7% of chromium are present in the irradiated [ 18 O]H 2 O in solid particles >5 μm in size. It was found that the main dose-providing chromium, manganese, cobalt, and beryllium radionuclides are hardly desorbed from QMA light in the elution of [ 18 F]fluoride with a K 2 CO 3 complex with cryptand [2.2.2] in an acetonitrile–water mixture, which provides a purification of these radionuclide impurities, with their amount reduced by a factor of 30–100. Nb, Ta, Re, and Tc radioisotopes are quantitatively sorbed on the anion-exchange cartridge and are mostly (up to 80% of the total activity) eluted together with [ 18 F]fluoride into a reactor for synthesis. The observed fundamental aspects of the distribution of long-lived radionuclides are explained with consideration for their chemical forms of existence in aqueous solutions and the properties of the sorbents used.
ISSN:1066-3622
1608-3288
DOI:10.1134/S1066362221020144