Ligational and biological studies of Fe(III), Co(II), Ni(II), Cu(II), and Zr(IV) complexes with carbamazepine as antiepileptic drug

Carbamazepine (CBZ) is considered to be the preferred drug for fractional seizures and may also use in the prevention of primary generalized tonic–clonic seizures. The chelates of CBZ with Fe(III), Co(II), Ni(II), Cu(II), and Zr(IV) were designed and characterized on the basis of elemental analysis,...

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Bibliographic Details
Published in:Applied organometallic chemistry 2021-05, Vol.35 (5), p.n/a
Main Authors: Mohamed, Amira A., Sadeek, Sadeek A.
Format: Article
Language:English
Subjects:
1HNMR
Antiinfectives and antibacterials
carbamazepine
Chelates
Chemical analysis
Chemistry
Cobalt
Coliforms
Convulsions & seizures
Copper
Differential thermal analysis
E coli
Endothermic reactions
Fungicides
Infrared analysis
Infrared spectroscopy
Iron
Ligands
Magnetic moments
Mass spectra
Mathematical analysis
Nickel
NMR
Nuclear magnetic resonance
Seizures
thermal analysis and antimicrobial effectiveness
Thermodynamic properties
UV‐visible
Water chemistry
Zirconium
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Summary:Carbamazepine (CBZ) is considered to be the preferred drug for fractional seizures and may also use in the prevention of primary generalized tonic–clonic seizures. The chelates of CBZ with Fe(III), Co(II), Ni(II), Cu(II), and Zr(IV) were designed and characterized on the basis of elemental analysis, FT‐IR, 1H NMR, UV‐visible, mass spectra, thermal analysis (TG, DTG, and DTA), molar conductivity, and magnetic moment. IR spectra emphasize that CBZ acts as a neutral bidentate ligand with metal ions through amide oxygen and amino nitrogen. UV‐visible spectra and magnetic moment demonstrate that all chelates have geometric octahedral structures. Complexes thermal behavior is systematically analyzed employing TG and DTA technicality. TG findings signalize that water molecules (hydrated and coordinated) are extracted the first and second phases, while CBZ ligand is splitted in the second and subsequent steps. From the DTA curves, the obtained data reflect that the degradation processes are endothermic or exothermic peaks. Assorted thermodynamic factors are calculated, and the results are explicated. Antimicrobial activity was examined against two Gram‐positive bacteria (Staphylococcus aureus and Bacillus subtilis) and two Gram‐negative bacteria (Escherichia coli and Pseudomonas aeuroginosa). Anti‐fungal efficacy of the compounds has been tested. The Co(II) complex was highly significant against the antifungal Candida albicans and significantly against Escherichia coli, Staphylococcus aureus, and Bacillus subtilis. A new series of Fe(III), Co(II), Cu(II), Ni(II), and Zr(IV) with carbamazepine as ligand (CBZ) have been synthesized and characterized. The chemical formulas, structures, and antimicrobial behavior were investigated.
ISSN:0268-2605
1099-0739
DOI:10.1002/aoc.6178