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Renal‐Clearable Ultrasmall Polypyrrole Nanoparticles with Size‐Regulated Property for Second Near‐Infrared Light‐Mediated Photothermal Therapy
The critical issue that hinders the translation of nanomaterials from basic research to clinical trials is their potential toxicity caused by long‐term body retention. It is still a huge challenge to integrate renal‐clearable and theranostic properties into one nanomedicine, especially exploring the...
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Published in: | Advanced functional materials 2021-04, Vol.31 (15), p.n/a |
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Main Authors: | , , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | The critical issue that hinders the translation of nanomaterials from basic research to clinical trials is their potential toxicity caused by long‐term body retention. It is still a huge challenge to integrate renal‐clearable and theranostic properties into one nanomedicine, especially exploring the nanomaterials with optical absorption in the second near‐infrared light (NIR II) biowindow with deep penetration and less tissue scattering. Here, ultrasmall polypyrrole (PPy, ≈2 nm)‐based theranostic agents via a facile and green one‐step method, which exhibit fluorescence (FL)/photoacoustic (PA)/NIR II multimodal imaging, superior photostability, as well as high photothermal conversion efficiency of 33.35% at 808 nm and 41.97% at 1064 nm is developed. Importantly, these ultrasmall PPy‐PEG nanoparticles (NPs) reveal abundant tumor accumulation and efficient renal clearance. Both in vitro and in vivo studies indicate that ultrasmall PPy‐PEG NPs have excellent photothermal effect under NIR II laser irradiation that can effectively eliminate the tumors with extremely low systemic toxicity.
Renal‐clearable second near‐infrared light‐mediated theranostic agents based on ultrasmall polypyrrole nanoparticles (PPy NPs) are elaborately synthesized via a facile and green one‐step method. The ultrasmall PPy NPs exhibit abundant tumor accumulation, an efficient renal metabolic pathway, and an excellent photothermal effect under NIR II laser irradiation, which guarantee the effective elimination of the malignant tumors with extremely low systemic toxicity. |
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ISSN: | 1616-301X 1616-3028 |
DOI: | 10.1002/adfm.202008362 |