Interaction of hypoxia and vascular occlusion on cardiorespiratory responses during exercise

Background The interaction of group III/IV afferents and chemoreflex during exercise is critical in healthy adults during high altitude exercise or in clinical populations who experience hypoxia. Purpose Investigate the cardiorespiratory response to simultaneous vascular occlusion (to activate group...

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Bibliographic Details
Published in:Translational sports medicine 2019-03, Vol.2 (2), p.64-72, Article tsm2.60
Main Authors: Keller‐Ross, Manda L., Sarkinen, Andrielle L., Chantigian, Daniel P., Cross, Troy J., Johnson, Bruce D., Olson, Thomas P.
Format: Article
Language:English
Subjects:
circulatory occlusion
group III and IV muscle afferents
Hypoxia
Vascular occlusion
ventilation and blood pressure
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Summary:Background The interaction of group III/IV afferents and chemoreflex during exercise is critical in healthy adults during high altitude exercise or in clinical populations who experience hypoxia. Purpose Investigate the cardiorespiratory response to simultaneous vascular occlusion (to activate group III/IV afferents) and hypoxia (to activate chemoreflex) during cycling exercise. Methods 18 adults (9 women, 25 ± 5 years) attended two sessions. Session 1: maximal cycle ergometry test. Session 2: two 26‐minute bouts (randomized between hypoxia, 12.5% FiO2 and normoxia, 21% FiO2). Participants cycled at 30% of peak workload for 3 minutes (control, CTL) followed by alternating 2 minute periods of bilateral vascular occlusion of the proximal thigh at pressures of 20, 40, 60, 80, 100 mm Hg in a randomized sequence. Results Ventilation (VE) increased from CTL to 100 mm Hg during hypoxia (39 ± 9 to 51 ± 16 L/min) and normoxia (31 ± 7 to 39 ± 9 L/min, P 
ISSN:2573-8488
2573-8488
DOI:10.1002/tsm2.60