Extracts of Jasminum sambac flowers fermented by Lactobacillus rhamnosus inhibit H2O2‐ and UVB‐induced aging in human dermal fibroblasts

Ultraviolet (UV) irradiation is a crucial factor that leads to skin photoaging and results in increased DNA damage, oxidative stress, and collagen degradation. Jasmine flowers have been utilized as a traditional medicine in Asia to treat various diseases, including dermatitis, diarrhea, and fever. F...

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Bibliographic Details
Published in:Environmental toxicology 2021-04, Vol.36 (4), p.607-619
Main Authors: Ho, Chih‐Chu, Ng, Shang‐Chuan, Chuang, Ho‐Lin, Wen, Su‐Ying, Kuo, Chia‐Hua, Mahalakshmi, B., Huang, Chih‐Yang, Kuo, Wei‐Wen
Format: Article
Language:English
Subjects:
Ageing
Aging
Aging (artificial)
Antioxidants
Cells
Collagen
Damage
Degradation
Deoxyribonucleic acid
Dermatitis
Diarrhea
DNA
DNA damage
Fermentation
fermented flower extract of Jasminum sambac
Fermented food
Fever
Fibroblasts
Flowers
Gene expression
H2O2
human skin fibroblast HS68 cells
Hydrogen peroxide
Inactivation
Irradiation
Jasminum sambac
Lactobacilli
Lactobacillus rhamnosus
MAP kinase
Medicine
Nuclear transport
Oxidative stress
Reactive oxygen species
Senescence
Skin
Smad2 protein
Transcription
Transcription factors
Translocation
ultraviolet B
Ultraviolet radiation
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Summary:Ultraviolet (UV) irradiation is a crucial factor that leads to skin photoaging and results in increased DNA damage, oxidative stress, and collagen degradation. Jasmine flowers have been utilized as a traditional medicine in Asia to treat various diseases, including dermatitis, diarrhea, and fever. Furthermore, the fermented broth of Lactobacillus rhamnosus has been reported to exert protective effects on the skin. In the present study, jasmine flower extract was fermented with L. rhamnosus. We investigated the antioxidant and collagen‐promoting effects on UVB/H2O2‐induced HS68 dermal fibroblast cell damage. The results indicated that treatment with the fermented flower extracts of Jasminum sambac (F‐FEJS) could enhance the viability of HS68 cells. Furthermore, the UVB/H2O2‐induced excessive production of reactive oxygen species, degradation of collagen, activation of MAPKs, including P38, ERK, and JNK, and premature senescence were remarkably attenuated by F‐FEJS in dermal fibroblast cells. The nuclear accumulation of p‐c‐jun, which is downstream of MAPK, and the inactivation of p‐smad2/3, which is one of the crucial transcription factors that enhance collagen synthesis, were reversed in response to F‐FEJS treatment in UVB/H2O2‐exposed cells. Notably, the expression of antioxidant genes, such as HO‐1, and the nuclear translocation of Nrf2 were further enhanced by F‐FEJS in UVB/H2O2‐treated cells. Interestingly, the F‐FEJS‐induced increase in ARE luciferase activity indicated the activation of Nrf2/ARE signaling. In conclusion, our findings demonstrated that F‐FEJS can effectively ameliorate UVB/H2O2‐induced dermal cell aging and may be considered a promising ingredient in skin aging therapy.
ISSN:1520-4081
1522-7278
DOI:10.1002/tox.23065