A pH-responsive ultrathin Cu-based nanoplatform for specific photothermal and chemodynamic synergistic therapy

Noninvasive tumor therapy requires a new generation of bionanomaterials towards sensitive response to the unique tumor microenvironment to achieve accurate and effective treatment. Herein, we have developed a tumor therapy nanoplatform by immobilizing natural glucose oxidase (GOD) onto Cu-based laye...

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Bibliographic Details
Published in:Chemical science (Cambridge) 2021-02, Vol.12 (7), p.2594-263
Main Authors: Hu, Tingting, Yan, Liang, Wang, Zhengdi, Shen, Weicheng, Liang, Ruizheng, Yan, Dongpeng, Wei, Min
Format: Article
Language:English
Subjects:
Acids
Chemistry
Glucose oxidase
Hydroxides
Hydroxyl radicals
Nanostructure
Photothermal conversion
Therapy
Tumors
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Summary:Noninvasive tumor therapy requires a new generation of bionanomaterials towards sensitive response to the unique tumor microenvironment to achieve accurate and effective treatment. Herein, we have developed a tumor therapy nanoplatform by immobilizing natural glucose oxidase (GOD) onto Cu-based layered double hydroxide (CuFe-LDH) nanosheets, which for the first time integrates acid-enhanced photothermal therapy (PTT), and pH-responsive and heat-facilitated chemodynamic therapy (CDT) simultaneously. As demonstrated by EXAFS and HRTEM, CuFe-LDH nanosheets possess a considerable number of defects caused by different acid conditions, resulting in a significantly acid-enhanced photothermal conversion efficiency (83.2% at pH 5.4 vs. 46.0% at pH 7.4). Moreover, GOD/CuFe-LDH nanosheets can convert a cascade of glucose into hydroxyl radicals (&z.rad;OH) under tumor acid conditions, which is validated by a high maximum velocity ( V max = 2.00 × 10 −7 M) and low Michaelis-Menten constant ( K M = 12.01 mM). With the combination of PTT and CDT, the tumor tissue in vivo is almost eliminated with low-dose drug injection (1 mg kg −1 ). Therefore, this novel pH-responsive Cu-based nanoplatform holds great promise in tumor-specific CDT/PTT synergistic therapy. A pH-responsive multifunctional nanosystem was synthesized by loading glucose oxidase (GOD) onto CuFe-layered double hydroxide (LDH) nanosheets, which exhibited synchronous acid-enhanced/responsive photothermal and chemodynamic synergistic therapy.
ISSN:2041-6520
2041-6539
DOI:10.1039/d0sc06742c