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N-(2,3,4,6-tetra-O-acetyl-β-d-glucopyranosyl)thiosemicarbazones of 6-alkoxy-2-oxo-2H-chromene-4-carbaldehydes: synthesis, evaluation of their antibacterial, anti-MRSA, antifungal activity, and docking study
Reaction of 6-alkoxy-2-oxo-2 H -chromen-4-carbaldehydes with N -(2,3,4,6-tetra- O -acetyl-β- d -glucopyranosyl)thiosemicarbazide yielded corresponding thiosemicarbazones having 2 H -chromen-2-one ring. In vitro evaluations showed that these 2 H -chromen-2-one compounds exhibited remarkable antibacte...
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Published in: | Medicinal chemistry research 2021-03, Vol.30 (3), p.743-759 |
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Main Authors: | , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Reaction of 6-alkoxy-2-oxo-2
H
-chromen-4-carbaldehydes with
N
-(2,3,4,6-tetra-
O
-acetyl-β-
d
-glucopyranosyl)thiosemicarbazide yielded corresponding thiosemicarbazones having 2
H
-chromen-2-one ring. In vitro evaluations showed that these 2
H
-chromen-2-one compounds exhibited remarkable antibacterial and antifungal activities against some typical bacteria and fungi. Representative compounds with MIC values of 0.78 − 1.56 μg/mL were
6c
,
6g
(against
S. aureus
),
6a
,
6f
(against
S. epidermidis
) (Gram-positive bacterial strains),
6e
,
6g
(against
E. coli
),
6b
,
6e
(against
K. pneumoniae
), and
6d
–
f
(against
S. typhimurium
) (Gram-negative bacterial strains). Almost all thiosemicarbazones
6a–g
had no activity against Gram-positive bacterial strain
B. subtilis
at these MIC values. Some compounds had strong inhibitory activity against several bacteria, such as
6b
(for
K. pneumoniae
and
S. typhimurium
),
6d
,
6e
(for
E. coli
,
K. pneumoniae
, and
S. typhimurium
),
6f
(for
S. aureus
,
E. coli
, and
S. typhimurium
), and
6g
(for
B. subtilis
,
S. aureus
,
E. coli
, and
K. pneumoniae
). Some compounds had remarkable inhibitory activity against three clinical MRSA isolates with MIC values of 0.78–6.25 μg/mL. Docking study showed that compound
6g
is compatible with the active site of
S. aureus
DNA gyrase 2XCT, which suggested that the tested compounds inhibited the synthesis of this enzyme. |
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ISSN: | 1054-2523 1554-8120 |
DOI: | 10.1007/s00044-020-02688-0 |