Disposable pencil graphite electrode decorated with a thin film of electro-polymerized 2, 3, 4, 6, 7, 8, 9, 10-octahydropyrimido [1, 2-a] azepine for simultaneous voltammetric analysis of dopamine, serotonin and tryptophan

A facile electrochemical sensor for the individual and simultaneous quantification for elevated levels of dopamine, tryptophan, and serotonin was fabricated on pencil graphite electrode modified with 2, 3, 4, 6, 7, 8, 9, 10-octahydropyrimido[1, 2-a] azepine. The fabricated electrode was characterize...

Full description

Saved in:
Bibliographic Details
Published in:Materials chemistry and physics 2021-01, Vol.258, p.123857, Article 123857
Main Authors: Rejithamol, R., Krishnan, Rajasree G., Beena, S.
Format: Article
Language:English
Subjects:
2, 3, 4, 6, 7, 8, 9, 10-octahydropyrimido[1,2-a] azepine
Anodizing
Chemical sensors
Dopamine
Electrodes
Graphite
Oxidation
Pencil graphite electrode
Polymerization
Serotonin
Thin films
Tryptophan
Voltammetry
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A facile electrochemical sensor for the individual and simultaneous quantification for elevated levels of dopamine, tryptophan, and serotonin was fabricated on pencil graphite electrode modified with 2, 3, 4, 6, 7, 8, 9, 10-octahydropyrimido[1, 2-a] azepine. The fabricated electrode was characterized by scanning electron microscopy and infrared spectroscopy. Voltammetric response of dopamine, tryptophan and serotonin on the electrode was attained by cyclic and differential pulse voltammetric techniques. Under experimental conditions, three well-separated irreversible oxidation peaks at +0.123 V, +0.302 V and +0.619 V were observed correspond to the oxidations of dopamine, serotonin and tryptophan. The anodic peak currents and the concentrations of dopamine, serotonin, and tryptophan were found to be linear in the range from 1 to 20 μM, 1–62 μM, and 1.5–750 μM with detection limits of 0.05, 0.27, and 0.05 μM, respectively. The linear ranges and the limits of detection for the simultaneous determination of these analytes are found to be superior to previously reported electrochemical sensors. The electropolymerization of 2, 3, 4, 6, 7, 8, 9, 10-octahydropyrimido[1, 2-a] azepine on a pencil graphite electrode is reported for the first time and the fabricated electrode is suitable for the determination of dopamine, serotonin and tryptophan in human blood and urine samples with good reproducibility and stability. [Display omitted] •For the first time reporting the electro polymerization of 2,3,4,6,7,8,9,10-octahydropyrimido[1,2-a]azepine.•Successfully fabricated the 2,3,4,6,7,8,9,10-octahydropyrimido[1,2-a]azepine modified disposable pencil graphite electrode.•Simultaneous and individual quantification of dopamine, serotonin and tryptophan.•The sensor is applicable for real sample analysis with high selectivity and sensitivity.
ISSN:0254-0584
1879-3312
DOI:10.1016/j.matchemphys.2020.123857