Spray Drying for Direct Compression of Pharmaceuticals

Tableting by direct compression (DC) is one of the simplest and most cost-effective drug manufacturing approaches. However, most active pharmaceutical ingredients (APIs) and excipients lack the compression and flow properties required to meet the needs of high-speed industrial tablet presses. Theref...

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Bibliographic Details
Published in:Processes 2021-02, Vol.9 (2), p.267
Main Authors: Al-Zoubi, Nizar, Gharaibeh, Shadi, Aljaberi, Ahmad, Nikolakakis, Ioannis
Format: Article
Language:English
Subjects:
Carbohydrates
Compression
Drug dosages
Drying
Excipients
Investigations
Particle size
Pharmaceuticals
Solvents
Spray drying
Viscosity
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Summary:Tableting by direct compression (DC) is one of the simplest and most cost-effective drug manufacturing approaches. However, most active pharmaceutical ingredients (APIs) and excipients lack the compression and flow properties required to meet the needs of high-speed industrial tablet presses. Therefore, the majority of DC APIs and excipients are modified via processing/co-processing particle engineering techniques to boost their properties. Spray drying is one of the most commonly employed techniques to prepare DC grades of APIs and excipients with prominent advantages. This review aims to present an overview of the commercially marketed and investigationally-prepared DC APIs and excipients produced by spray drying.
ISSN:2227-9717
2227-9717
DOI:10.3390/pr9020267