Cholesterol free niosome production by microfluidics: Comparative with other conventional methods

[Display omitted] •Monodispersed controlled size niosomes production by Microfluidics (MF) was studied.•Tween® 80 and Span® 80 were used in presence and absence of Dodecanol.•Results were compared to Thin Film Hydration (TFH) and Ethanol Injection (EI) methods.•MF showed an accurate control of the f...

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Bibliographic Details
Published in:Chemical engineering research & design 2020-10, Vol.162, p.162-171
Main Authors: Machado, Noelia D., García-Manrique, Pablo, Fernández, Mariana A., Blanco-López, Maria Carmen, Matos, María, Gutiérrez, Gemma
Format: Article
Language:English
Subjects:
Cholesterol
Design of experiments
Dodecanol
Ethanol
Ethanol injection
Flow velocity
Formulations
Membranes
Microfluidics
Nanovesicles monodispersity
Niosomes
Optimization
Parameters
Pharmaceutical industry
Polydispersity
Size control
Size distribution
Thin film hydration
Thin films
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Summary:[Display omitted] •Monodispersed controlled size niosomes production by Microfluidics (MF) was studied.•Tween® 80 and Span® 80 were used in presence and absence of Dodecanol.•Results were compared to Thin Film Hydration (TFH) and Ethanol Injection (EI) methods.•MF showed an accurate control of the final size of the niosomes produced.•MF were smaller and more homogeneous to those achieved by TFH and similar to IE. The extended use of niosomes in food, cosmetic and pharmaceutical industries demands novel preparation processes which could enhance nanovesicles production with controlled size and size distribution. Microfluidics (MF) are a novel promising set of preparation methods for this purpose. Studies comparing methods for niosome preparation are still scarce. In this work, niosomes using MF were produced and the effect of membrane compounds concentration and the relation between organic and aqueous ratio (flow rate ratio, FRR) on the resulting mean size and size distribution were studied. Two different cholesterol free formulations were tested using Tween® 80 and Span® 80 in presence and absence of 1-dodecanol as membrane stabilizer. The effect of FRR showed to be the key parameter in niosomes production, being more critical than membrane compounds concentration and the vesicle membrane composition. Additionally, the same formulations were also produced by two conventional methods, thin film hydration (TFH) and ethanol injection (EI), and results were compared. The size of the niosomes obtained by MF was smaller and more homogeneous than those achieved by TFH and similar to EI. Therefore, MF is confirmed as a novel technology that can facilitate the development and optimization of new nanodelivery systems with controlled size and polydispersity, two essential parameters for successful biotechnological applications.
ISSN:0263-8762
1744-3563
DOI:10.1016/j.cherd.2020.08.002