The effects of mesenchymal stem cell mitochondrial transplantation on doxorubicin‐mediated nephrotoxicity in rats

The effect of dysfunctional mitochondria in several cell pathologies has been reported in renal diseases, including diabetic nephropathy and acute kidney injury. Previous studies have reported that mitochondrial transplantation provided surprising results in myocardial and liver ischemia, as well as...

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Bibliographic Details
Published in:Journal of biochemical and molecular toxicology 2021-01, Vol.35 (1), p.e22612-n/a
Main Authors: Kubat, Gokhan Burcin, Ozler, Mehmet, Ulger, Oner, Ekinci, Ozgur, Atalay, Ozbeyen, Celik, Ertugrul, Safali, Mukerrem, Budak, Murat Timur
Format: Article
Language:English
Subjects:
Caspase
Diabetes mellitus
Diabetic nephropathy
Doxorubicin
Injury prevention
Ischemia
Kidney transplantation
Kidneys
mesenchymal stem cell
Mesenchymal stem cells
Mitochondria
mitochondrial transplantation
Movement disorders
Nephropathy
Neurodegenerative diseases
Oxidative stress
Parkinson's disease
rat
Regeneration
Renal cortex
renal injury
Stem cell transplantation
Stem cells
Transplantation
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Summary:The effect of dysfunctional mitochondria in several cell pathologies has been reported in renal diseases, including diabetic nephropathy and acute kidney injury. Previous studies have reported that mitochondrial transplantation provided surprising results in myocardial and liver ischemia, as well as in Parkinson's disease. We aimed to investigate the beneficial effects of isolated mitochondria transplantation from mesenchymal stem cells (MSCs) in vivo, to mitigate renal damage that arises from doxorubicin‐mediated nephrotoxicity and its action mechanism. In this study, a kidney model of doxorubicin‐mediated nephrotoxicity was used and isolated mitochondria from MSCs were transferred to the renal cortex of rats. The findings showed that the rate of isolated mitochondria from MSCs maintains sufficient membrane integrity, and was associated with a beneficial renal therapeutic effect. Following doxorubicin‐mediated renal injury, isolated mitochondria or vehicle infused into the renal cortex and rats were monitored for five days. This study found that mitochondrial transplantation decreased cellular oxidative stress and promoted regeneration of tubular cells after renal injury (P 
ISSN:1095-6670
1099-0461
DOI:10.1002/jbt.22612