2-Ethyl-3-hydroxy-6-methylpyridine nitroxy succinate as a multifunctional hybrid structure

The effect of 2-ethyl-3-hydroxy-6-methylpyridine nitroxy succinate (1) on heart, brain, and liver tissues of experimental animals (C57/b1 mice) was studied by EPR. It was shown that compound 1, like nicorandil, increases the nitric oxide production in cells and, like mexidol, protects iron-sulfur cl...

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Bibliographic Details
Published in:Russian chemical bulletin 2020-10, Vol.69 (10), p.1999-2003
Main Authors: Bogatyrenko, T. N., Kuropteva, Z. V., Baider, L. M., Bogatyrenko, V. R., Mishchenko, D. V.
Format: Article
Language:English
Subjects:
Animals
Brain damage
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Clusters
Full Articles
Hybrid structures
Inorganic Chemistry
Iron
Liver
Metabolites
Nitric oxide
Organic Chemistry
Succinic acid
Sulfur
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Summary:The effect of 2-ethyl-3-hydroxy-6-methylpyridine nitroxy succinate (1) on heart, brain, and liver tissues of experimental animals (C57/b1 mice) was studied by EPR. It was shown that compound 1, like nicorandil, increases the nitric oxide production in cells and, like mexidol, protects iron-sulfur clusters of the mitochondrial respiratory chain in heart, brain, and liver tissues of animals against oxidative damage. Experimental evidence was obtained that under oxidative conditions, mitochondrial iron-sulfur clusters are maintained in the reduced functional state due to the presence of succinate (as nitroxy succinic acid), as a metabolite of the tricarboxylic acid cycle, in compound 1 .
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-020-2991-4